Non-invasive brain stimulation for patient with autism: a systematic review and meta-analysis

Frontiers in Psychiatry

Psychiatry

Bobo Wang¹  Jiaxing Sun¹  Chao Gong¹  Annan Liu²  Zhimei Jiang³ 

[1] Jiamusi Medical College, Jiamusi, Heilongjiang, China;Jiamusi University Affiliated No.3 Hospital, Jiamusi, China;Jiamusi University College of Rehabilitation Medicine, Jiamusi, Heilongjiang, China;

关键词: autism;    non-invasive neurostimulation;    transcranial direct current stimulation;    transcranial magnetic stimulation;    meta-analysis;   

DOI  :  10.3389/fpsyt.2023.1147327

 received in 2023-01-18, accepted in 2023-06-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveTo comprehensively evaluate the efficacy of non-invasive brain stimulation (NIBS) in patients with autism spectrum disorder (ASD) in randomized controlled trials (RCT), providing a reference for future research on the same topic.MethodsFive databases were searched (Pubmed, Web of Science, Medline, Embase, and Cochrane library) and tracked relevant references, Meta-analysis was performed using RevMan 5.3 software.ResultsTwenty-two references (829 participants) were included. The results of the meta-analysis showed that NIBS had positive effects on repetitive and stereotypical behaviors, cognitive function, and executive function in autistic patients. Most of the included studies had a moderate to high risk of bias, Mainly because of the lack of blinding of subjects and assessors to treatment assignment, as well as the lack of continuous observation of treatment effects.ConclusionAvailable evidence supports an improvement in some aspects of NIBS in patients with ASD. However, due to the quality of the original studies and significant publication bias, this evidence must be treated with caution. Further large multicenter randomized double-blind controlled trials and appropriate follow-up observations are needed to further evaluate the specific efficacy of NIBS in patients with ASD.

【 授权许可】

Unknown   
Copyright © 2023 Liu, Chao, Wang, Sun and Jiang.