Influence and risk factors of postoperative infection after surgery for ischemic cardiomyopathy

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Yang Lu¹  Fuqiang Sun²  Chao Liu²  Bing Wen²  Fei Xie²  Dashuai Wang²  Xinling Du³  Xiaofan Huang³ 

[1] Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Cardiovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

关键词: postoperative infection;    heart failure;    ischemic cardiomyopathy;    coronary artery disease (CAD);    coronary artery bypass graft (CABG);   

DOI  :  10.3389/fcvm.2023.1231556

 received in 2023-05-30, accepted in 2023-08-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundStudies on postoperative infection (POI) after surgery for ischemic cardiomyopathy are still lacking. This study aimed to investigate the risk factors of POI and its influence on clinical outcomes in patients undergoing ischemic cardiomyopathy surgery.MethodsThe Surgical Treatment for Ischemic Heart Failure (STICH) trial randomized patients with ischemic cardiomyopathy [coronary artery disease (CAD) with left ventricular ejection fraction ≤35%] to surgical and medical therapy. In this study, a post hoc analysis of the STICH trial was performed to assess the risk factors and clinical outcomes of POI in those undergoing coronary artery bypass graft (CABG). Patients were divided according to whether POI developed during hospitalization or within 30 days from operation.ResultsOf the 2,136 patients randomized, 1,460 patients undergoing CABG per-protocol was included, with a POI rate of 10.2% (149/1,460). By multivariable analysis, POI was significantly related to patients' age, body mass index, depression, chronic renal insufficiency, Duke CAD Index, and mitral valve procedure. Compared to patients without POI, patients with POI had significantly longer durations of intubation, CCU/ICU and hospital stay, and higher rates of re-operation, in-hospital death and failed discharge within 30 days postoperatively. In addition, these patients had significantly higher risks of all-cause death, cardiovascular death, heart failure death, and all-cause hospitalization during long-term follow-up. However, the influence of POI on all-cause death was mainly found during the first year after operation, and the influence was not significant for patients surviving for more than 1 year.ConclusionsPOI was prevalent after surgery for ischemic cardiomyopathy and was closely related to short-term and long-term clinical outcomes, and the effect of POI mainly occurred within the first postoperative year. This study first reported and clarified the relationship between POI and long-term prognosis and the predictors for POI after surgery for ischemic cardiomyopathy worldwide, which may have certain guiding significance for clinical practice.Clinical Trial Registrationhttps://www.clinicaltrials.gov, identifier (NCT00023595).

【 授权许可】

Unknown   
© 2023 Wen, Lu, Huang, Du, Sun, Xie, Liu and Wang.