Animal models for COVID-19 and tuberculosis

Frontiers in Immunology

Immunology

Max Bastian¹  Martin Beer²  Donata Hoffmann²  Björn Corleis³  Anca Dorhoi⁴ 

[1] Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany;Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany;Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany;Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany;Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany;

关键词: animal model;    mycobacteria;    tuberculosis;    SARS-CoV-2;    COVID-19;    immunology;    pathology;    respiratory infection;   

DOI  :  10.3389/fimmu.2023.1223260

 received in 2023-05-15, accepted in 2023-07-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

Respiratory infections cause tremendous morbidity and mortality worldwide. Amongst these diseases, tuberculosis (TB), a bacterial illness caused by Mycobacterium tuberculosis which often affects the lung, and coronavirus disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), stand out as major drivers of epidemics of global concern. Despite their unrelated etiology and distinct pathology, these infections affect the same vital organ and share immunopathogenesis traits and an imperative demand to model the diseases at their various progression stages and localizations. Due to the clinical spectrum and heterogeneity of both diseases experimental infections were pursued in a variety of animal models. We summarize mammalian models employed in TB and COVID-19 experimental investigations, highlighting the diversity of rodent models and species peculiarities for each infection. We discuss the utility of non-human primates for translational research and emphasize on the benefits of non-conventional experimental models such as livestock. We epitomize advances facilitated by animal models with regard to understanding disease pathophysiology and immune responses. Finally, we highlight research areas necessitating optimized models and advocate that research of pulmonary infectious diseases could benefit from cross-fertilization between studies of apparently unrelated diseases, such as TB and COVID-19.

【 授权许可】

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Copyright © 2023 Corleis, Bastian, Hoffmann, Beer and Dorhoi