Functional and structural lesion network mapping in neurological and psychiatric disorders: a systematic review

Frontiers in Neurology

Neurology

Mohammad Hadi Aarabi¹  Fardin Nabizadeh² 

[1] Department of Neuroscience and Padova Neuroscience Center (PNC), University of Padova, Padua, Italy;Neuroscience Research Group (NRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran;School of Medicine, Iran University of Medical Sciences, Tehran, Iran;

关键词: lesion network mapping;    connectivity;    lesions;    stroke;    network;    localization;   

DOI  :  10.3389/fneur.2023.1100067

 received in 2022-11-16, accepted in 2023-06-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe traditional approach to studying the neurobiological mechanisms of brain disorders and localizing brain function involves identifying brain abnormalities and comparing them to matched controls. This method has been instrumental in clinical neurology, providing insight into the functional roles of different brain regions. However, it becomes challenging when lesions in diverse regions produce similar symptoms. To address this, researchers have begun mapping brain lesions to functional or structural networks, a process known as lesion network mapping (LNM). This approach seeks to identify common brain circuits associated with lesions in various areas. In this review, we focus on recent studies that have utilized LNM to map neurological and psychiatric symptoms, shedding light on how this method enhances our understanding of brain network functions.MethodsWe conducted a systematic search of four databases: PubMed, Scopus, and Web of Science, using the term “Lesion network mapping.” Our focus was on observational studies that applied lesion network mapping in the context of neurological and psychiatric disorders.ResultsFollowing our screening process, we included 52 studies, comprising a total of 6,814 subjects, in our systematic review. These studies, which utilized functional connectivity, revealed several regions and network overlaps across various movement and psychiatric disorders. For instance, the cerebellum was found to be part of a common network for conditions such as essential tremor relief, parkinsonism, Holmes tremor, freezing of gait, cervical dystonia, infantile spasms, and tics. Additionally, the thalamus was identified as part of a common network for essential tremor relief, Holmes tremor, and executive function deficits. The dorsal attention network was significantly associated with fall risk in elderly individuals and parkinsonism.ConclusionLNM has proven to be a powerful tool in localizing a broad range of neuropsychiatric, behavioral, and movement disorders. It holds promise in identifying new treatment targets through symptom mapping. Nonetheless, the validity of these approaches should be confirmed by more comprehensive prospective studies.

【 授权许可】

Unknown   
Copyright © 2023 Nabizadeh and Aarabi.