The effect of terminal impedance on aortic morphology and hemodynamics: an in vitro phantom study using flow field visualization

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Wenjun Wang¹  Yi Yang²  Huimin Chen³  Qingzhuo Chi³  Dengji Liu³  Zhen Cao³  Ying He³ 

[1] Department of Cardiovascular Surgery, Dalian Municipal Central Hospital, Dalian, China;Department of Neurosurgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China;Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education, School of Energy and Power Engineering, Dalian University of Technology, Dalian, China;

关键词: aortic dissection;    in vitro;    silicone phantom;    terminal impedance;    particle image velocimetry;   

DOI  :  10.3389/fbioe.2023.1175916

 received in 2023-02-28, accepted in 2023-04-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

To investigate the risk factors for aortic dissection tearing, we fabricated a simplified patient-specific aortic silicone phantom using the brush-spin-coating method. The aortic phantom only includes the aorta from the ascending aorta to the descending aorta, without other branches. We designed two experiments to investigate the alteration of aortic morphology and intravascular hemodynamics using the particle image velocimetry method. The results revealed dilation and elongation of the aortic phantom, especially the ascending aorta, after the phantom’s terminal resistance was increased. Additionally, the particle image velocimetry results demonstrated an increased vortex region, which caused the inner side of the aortic wall to become scoured by blood. This study suggests that the deformation of the inner side aortic wall and the change in hemodynamics in response to the increased terminal resistance may be a risk factor for aortic tearing and should be monitored.

【 授权许可】

Unknown   
Copyright © 2023 Chen, Wang, Liu, Cao, Yang, He and Chi.