Altered coupling of resting-state cerebral blood flow and functional connectivity in Meige syndrome

Frontiers in Neuroscience

Neuroscience

Hong Tian¹  Hongwei Yu²  Aocai Yang³  Bing Liu³  Guolin Ma³  Jixin Luan³  Kuan Lv⁴  Pianpian Hu⁴  Shijun Li⁵  Bing Zhang⁶  Amir Shmuel⁷ 

[1] Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China;Department of Radiology, China-Japan Friendship Hospital, Beijing, China;Department of Radiology, China-Japan Friendship Hospital, Beijing, China;Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;Department of Radiology, China-Japan Friendship Hospital, Beijing, China;Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China;Department of Radiology, First Medical Center of Chinese PLA General Hospital, Beijing, China;Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Beijing, China;McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada;Departments of Neurology and Neurosurgery, Physiology, and Biomedical Engineering, McGill University, Montreal, QC, Canada;

关键词: Meige syndrome;    arterial spin labeling;    cerebral blood flow;    functional magnetic resonance imaging;    functional connectivity strength;   

DOI  :  10.3389/fnins.2023.1152161

 received in 2023-01-27, accepted in 2023-03-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionMeige syndrome (MS) is an adult-onset segmental dystonia disease, mainly manifested as blepharospasm and involuntary movement caused by dystonic dysfunction of the oromandibular muscles. The changes of brain activity, perfusion and neurovascular coupling in patients with Meige syndrome are hitherto unknown.MethodsTwenty-five MS patients and thirty age- and sex-matched healthy controls (HC) were prospectively recruited in this study. All the participants underwent resting-state arterial spin labeling and blood oxygen level-dependent examinations on a 3.0 T MR scanner. The measurement of neurovascular coupling was calculated using cerebral blood flow (CBF)-functional connectivity strength (FCS) correlations across the voxels of whole gray matter. Also, voxel-wised analyses of CBF, FCS, and CBF/FCS ratio images between MS and HC were conducted. Additionally, CBF and FCS values were compared between these two groups in selected motion-related brain regions.ResultsMS patients showed increased whole gray matter CBF-FCS coupling relative to HC (t = 2.262, p = 0.028). In addition, MS patients showed significantly increased CBF value in middle frontal gyrus and bilateral precentral gyrus.ConclusionThe abnormal elevated neurovascular coupling of MS may indicate a compensated blood perfusion in motor-related brain regions and reorganized the balance between neuronal activity and brain blood supply. Our results provide a new insight into the neural mechanism underlying MS from the perspective of neurovascular coupling and cerebral perfusion.

【 授权许可】

Unknown   
Copyright © 2023 Yang, Liu, Lv, Luan, Hu, Yu, Shmuel, Li, Tian, Ma and Zhang.