Linking cell cycle to hematopoietic stem cell fate decisions

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Marie-Dominique Filippi¹  Sydney Treichel² 

[1] Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children’s Hospital Research Foundation, Cincinnati, OH, United States;University of Cincinnati College of Medicine, Cincinnati, OH, United States;Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children’s Hospital Research Foundation, Cincinnati, OH, United States;University of Cincinnati College of Medicine, Cincinnati, OH, United States;Molecular and Development Biology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, United States;

关键词: hematopoietic stem cells;    cell cycle;    fate decision;    differentiation;    asymmetric division;   

DOI  :  10.3389/fcell.2023.1231735

 received in 2023-05-30, accepted in 2023-07-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

Hematopoietic stem cells (HSCs) have the properties to self-renew and/or differentiate into any blood cell lineages. In order to balance the maintenance of the stem cell pool with supporting mature blood cell production, the fate decisions to self-renew or to commit to differentiation must be tightly controlled, as dysregulation of this process can lead to bone marrow failure or leukemogenesis. The contribution of the cell cycle to cell fate decisions has been well established in numerous types of stem cells, including pluripotent stem cells. Cell cycle length is an integral component of hematopoietic stem cell fate. Hematopoietic stem cells must remain quiescent to prevent premature replicative exhaustion. Yet, hematopoietic stem cells must be activated into cycle in order to produce daughter cells that will either retain stem cell properties or commit to differentiation. How the cell cycle contributes to hematopoietic stem cell fate decisions is emerging from recent studies. Hematopoietic stem cell functions can be stratified based on cell cycle kinetics and divisional history, suggesting a link between Hematopoietic stem cells activity and cell cycle length. Hematopoietic stem cell fate decisions are also regulated by asymmetric cell divisions and recent studies have implicated metabolic and organelle activity in regulating hematopoietic stem cell fate. In this review, we discuss the current understanding of the mechanisms underlying hematopoietic stem cell fate decisions and how they are linked to the cell cycle.

【 授权许可】

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Copyright © 2023 Treichel and Filippi.