Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements

Frontiers in Veterinary Science

Veterinary Science

Santiago Peralta¹  Alexandra L. Wright¹  Nadine Fiani¹  Christine Austin²  Manish Arora² 

[1] Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States;Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States;Icahn School of Medicine at Mount Sinai, Institute for Exposomic Research, New York, NY, United States;

关键词: feline;    trace elements;    dental;    exposure;    toxin;    mass spectromotry;   

DOI  :  10.3389/fvets.2023.1204210

 received in 2023-04-11, accepted in 2023-06-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionTrace elements play a key role in dental tissue development, as dental hard tissues accumulate both essential and toxic trace elements during mineralization. Characterization of the spatial accumulation pattern of trace elements may provide insight into exposure to toxic elements over time and to the nature of disease processes affecting the hard dental tissues. Here, we present the first report of the use of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) to map the microspatial distribution of multiple trace elements, essential and toxic, across feline dental hard tissues.MethodsEleven teeth were extracted from 8 cats. Nine teeth were from 7 cats diagnosed with idiopathic tooth resorption on intraoral radiographs prior to extraction. Two teeth were included from a cadaver that had no signs of tooth resorption on intraoral radiographs. The normal dental tissue was analyzed from each sample using LA-ICP-MS to map the microspatial distribution of essential and toxic trace elements across feline enamel, dentin, and cementum.ResultsResults showed a higher accumulation of barium and strontium in coronal dentin as compared to root dentin. The timing of the accumulation mirrors nursing timelines seen in teeth from human and non-human primates, consistent with barium and strontium being sourced from maternal milk. Results also showed a higher uptake of lead in the coronal dentin, suggesting this lead exposure was likely passed from mother to offspring.DiscussionThis work characterizes a baseline for elemental distribution in feline teeth linked to early life exposure to toxic elements such as lead and provides a framework for future studies investigating long-term environmental exposures to trace elements, essential and toxic, and their involvement in feline systemic and dental diseases.

【 授权许可】

Unknown   
Copyright © 2023 Wright, Fiani, Peralta, Arora and Austin.