Peroxidase-like MoS2/Ag nanosheets with synergistically enhanced NIR-responsive antibacterial activities

Frontiers in Chemistry

Chemistry

Xinshuo Zhao¹  Jingguo Li²  Mengyang Zhao²  Zhan Zhou³  Huiying Chen⁴  Haohao Cui⁴  Bingbing Cui⁴  Jun Shi⁵ 

[1] Henan Key Laboratory of Function-Oriented Porous Materials, College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, China;Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, China;Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, China;Henan Key Laboratory of Function-Oriented Porous Materials, College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, China;Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, China;School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, China;School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, China;

关键词: two-dimensional;    silver nanoparticles;    photo-responsive;    peroxidase-like activity;    synergistic antibacterial;   

DOI  :  10.3389/fchem.2023.1148354

 received in 2023-01-23, accepted in 2023-02-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Pathogenic microbial infections have been threatening public health all over the world, which makes it highly desirable to develop an antibiotics-free material for bacterial infection. In this paper, molybdenum disulfide (MoS2) nanosheets loaded with silver nanoparticles (Ag NPs) were constructed to inactive bacteria rapidly and efficiently in a short period under a near infrared (NIR) laser (660 nm) in the presence of H2O2. The designed material presented favorable features of peroxidase-like ability and photodynamic property, which endowed it with fascinating antimicrobial capacity. Compared with free MoS2 nanosheets, the MoS2/Ag nanosheets (denoted as MoS2/Ag NSs) exhibited better antibacterial performance against Staphylococcus aureus by the generated reactive oxygen species (ROS) from both peroxidase-like catalysis and photodynamic, and the antibacterial efficiency of MoS2/Ag NSs could be further improved by increasing the amount of Ag. Results from cell culture tests proved that MoS2/Ag3 nanosheets had a negligible impact on cell growth. This work provided new insight into a promising method for eliminating bacteria without using antibiotics, and could serve as a candidate strategy for efficient disinfection to treat other bacterial infections.

【 授权许可】

Unknown   
Copyright © 2023 Chen, Zhao, Cui, Cui, Zhao, Shi, Li and Zhou.