Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation

Frontiers in Pharmacology

Pharmacology

Ping-Chuan Yuan¹  Hui Zhang¹  Michael Lazarus²  Wei-Xiang Ma³  Zhi-Li Huang³  Wei-Min Qu³  Ling-Xi Kong³  Yi-Qun Wang³ 

[1] Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, China;International Institute for Integrative Sleep Medicine (WPI-IIIS) and Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan;State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Department of Pharmacology, School of Basic Medical Sciences, Institutes of Brain Science, Fudan University, Shanghai, China;

关键词: adenosine;    P1 receptors;    hibernation;    sleep;    torpor;   

DOI  :  10.3389/fphar.2023.1098976

 received in 2022-11-15, accepted in 2023-02-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

Sleep, torpor, and hibernation are three distinct hypometabolic states. However, they have some similar physiological features, such as decreased core body temperature and slowing heart rate. In addition, the accumulation of adenosine seems to be a common feature before entry into these three states, suggesting that adenosine and its receptors, also known as P1 receptors, may mediate the initiation and maintenance of these states. This review, therefore, summarizes the current research on the roles and possible neurobiological mechanisms of adenosine and P1 receptors in sleep, torpor, and hibernation. Understanding these aspects will give us better prospects in sleep disorders, therapeutic hypothermia, and aerospace medicine.

【 授权许可】

Unknown   
Copyright © 2023 Ma, Yuan, Zhang, Kong, Lazarus, Qu, Wang and Huang.