The occurrence of acute primary angle closure triggered, aggravated, and accelerated by COVID-19 infection: retrospective observational study

Frontiers in Public Health

Public Health

Xiangmei Kong¹  Qilian Sheng¹  Xintong Fan¹  Yue Ying¹  Ruyi Zhai¹  Yanan Sun¹ 

[1] Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China;NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, China;Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China;

关键词: acute primary angle closure;    COVID-19;    ultrasound biomicroscope;    SARS-COV-2;    pathogenesis;    elevated intraocular pressure;   

DOI  :  10.3389/fpubh.2023.1196202

 received in 2023-03-29, accepted in 2023-07-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionThe aim of this study is to demonstrate the relevance of primary acute angle closure (APAC) and COVID-19 infection, compare the demographic features and manifestations between COVID-19 positive and negative patients with APAC, and infer the underlying mechanism.MethodsThis study is based on all patients diagnosed with APAC at the glaucoma center of Eye, Ear, Nose and Throat Hospital of Fudan University (Fenyang road center) from 15th December 2022 to 11th January 2023. Totally 171 APAC cases were categorized into COVID-19 positive and negative group. Demographic features and final treatment level of the patients were compared between the two groups. Clinical manifestations, intraocular pressure, and anterior chamber configuration were also compared between the two groups.ResultsIn the COVID-19 positive group, the number of cases with APAC onset spiked in 22nd December 2022, which coincided with the spike of COVID-19 antigen positive people. Compared to the COVID-19 negative group, COVID-19 positive APAC patients were younger with a lower percentage of APAC history. Additionally, more eyes of COVID-19 positive APAC patients showed keratic precipitates. COVID-19 positive eyes had significantly larger anterior chamber depth with a more dilated pupil. Therefore, COVID-19 infection could probably act as a triggering factor of APACDiscussionThe onset of APAC might be accelerated by COVID-19 infection for patients with younger age and milder anatomical configuration. Additionally, COVID-19 related APAC cases might have a more abrupt and fierce onset. Ophthalmic emergent services should not be neglected during the epidemic period.

【 授权许可】

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Copyright © 2023 Ying, Zhai, Sun, Sheng, Fan and Kong.