A composite score based on immune-related gene prognostic index and m6A risk score of head and neck squamous cell carcinoma

Frontiers in Genetics

Genetics

Kaichun Huang¹  Zeman Cai¹  Mei Li¹  Zhining Yang²  Yinbing Lin³  Sijie Chen³  Xiao Wang³  Zhixiong Lin³  Yizhou Yang³ 

[1] Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China;Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China;Nasopharyngeal Carcinoma Research Center of Shantou University Medical College, Shantou, Guangdong, China;Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China;Nasopharyngeal Carcinoma Research Center of Shantou University Medical College, Shantou, Guangdong, China;Shantou University Medical College, Shantou, Guangdong, China;

关键词: head and neck squamous cell carcinoma;    mA;    immunotherapy;    tumor immune microenvironment;    prognosis;   

DOI  :  10.3389/fgene.2023.1061569

 received in 2022-11-09, accepted in 2023-01-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background: Immunotherapy has been demonstrated favorable in head and neck squamous cell carcinoma (HNSCC). Studies indicated that immune-related gene prognostic index (IRGPI) was a robust signature, and N6-methyladenosine (m6A) methylation had a significant impact on the tumor immune microenvironment (TIME) and immunotherapy of head and neck squamous cell carcinoma. Thus, combining indicated that immune-related gene prognostic index with m6A status should offer a better predictive power for immune responses.Methods: Head and neck squamous cell carcinoma samples from the cancer genome atlas (TCGA, n = 498) and gene expression omnibus database (GSE65858, n = 270) were used in this study. Cox regression analysis was used to construct the indicated that immune-related gene prognostic index through immune-related hub genes which were identified by weighted gene co-expression network analysis (WGCNA). The m6A risk score was constructed by least absolute shrinkage and selection operator (LASSO) regression analysis. Principal component analysis was used to construct a composite score, and systematically correlate subgroups according to tumor immune microenvironment cell-infiltrating characteristics.Results: A composite score was determined based on indicated that immune-related gene prognostic index and m6A risk score. Head and neck squamous cell carcinoma patients in the cancer genome atlas were divided into four subgroups: A (IRGPI-High&m6A-risk-High, n = 127), B (IRGPI-High&m6A-risk-Low, n = 99), C (IRGPI-Low&m6A-risk-High, n = 99), and D (IRGPI-Low&m6A-risk-Low, n = 128), and overall survival (OS) was significantly different between subgroups (p < 0.001). The characteristics of tumor immune microenvironment cell infiltration in the four subgroups were significantly different in subgroups (p < 0.05). The receiver operating characteristic (ROC) curves show the predictive value of composite score for overall survival was superior to other scores.Conclusion: The composite score is a promising prognostic signature which might distinguish immune and molecular characteristics, predict prognosis, and guide more effective immunotherapeutic strategies for head and neck squamous cell carcinoma.

【 授权许可】

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Copyright © 2023 Yang, Cai, Huang, Li, Wang, Lin, Chen, Yang and Lin.