The correlation between peripheral complete blood count parameters and diabetic macular edema in proliferative diabetic retinopathy patients: a cross-sectional study

Frontiers in Endocrinology

Endocrinology

Meixia Zhang¹  Keren Zhang¹  Jinyue Gu¹  Chunyan Lei¹  Lili Liu² 

[1] Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China;Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, China;Department of Ophthalmology, Zigong First People’s Hospital, Zigong, China;

关键词: diabetic macular edema;    proliferative diabetic retinopathy;    peripheral complete blood count;    inflammation;    white blood cell (WBC);   

DOI  :  10.3389/fendo.2023.1190239

 received in 2023-03-20, accepted in 2023-06-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundNumerous studies have demonstrated that retinal chronic inflammation plays a critical role in the pathogenesis of diabetic macular edema (DME). However, studies about the association between peripheral complete blood count, an inexpensive and easily measurable laboratory index, and DME are limited.Research design and methodsThe current study was a hospital-based, cross-sectional study. The participants were inpatients with type 2 diabetes who underwent vitrectomy for PDR, and the contralateral eyes in these PDR patients meeting the criteria were included in the study. Central macular thickness (CMT) was measured automatically and the DME was characterized as CMT ≥ 300 μm.ResultsA total of 239 PDR participants were enrolled. The average age was 55.46 ± 10.08 years old, and the average CMT was 284.23 ± 122.09 μm. In the fully adjusted model, for CMT, the results revealed a significantly negative association between CMT and both white blood cell (WBC) count and neutrophil count (β = −11.95, 95% CI: −22.08, −1.82; p = 0.0218; β = −14.96, 95% CI: −28.02, −1.90; p = 0.0259, respectively); for DME, the results showed an inverse association between DME and WBC count, monocyte count, and eosinophil count (OR = 0.75, 95% CI: 0.59, 0.95; p = 0.0153; OR = 0.07, 95% CI: 0.00, 0.92; p = 0.0431; OR = 0.03, 95% CI: 0.00, 0.88; p = 0.0420, respectively).ConclusionsIn conclusion, our results suggest that WBC and its subtypes in circulation may play an important role in the pathogenesis of DME in PDR patients.

【 授权许可】

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Copyright © 2023 Lei, Gu, Liu, Zhang and Zhang