Skin infectome of patients with a tick bite history

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Jin-Ling Ye¹  Yan-Li Chu¹  Qiu-Bo Huo¹  Nan-Nan Yao¹  Cai Bian¹  Yuan-Chun Zheng¹  Ju-Liang Song¹  Mei-Chao Chen²  Yan Gao²  Jin-Guo Zhu²  Fei Wang²  Hong-Bo Liu³  Lin Zhao⁴  Lian-Feng Li⁴  Rui-Ruo Jiang⁵  Ting-Ting Yuan⁶  Xue-Bing Ni⁷  Tommy Tsan-Yuk Lam⁷  Xiao-Ming Cui⁸  Na Jia⁸  Jie Zhang⁸  Qian Wang⁸  Wei Wei⁸  Jie Li⁸  Jia-Fu Jiang⁸  Ran Wei⁹ 

[1] Department of Cardiology, Mudanjiang Forestry Central Hospital, Mudanjiang, China;Department of Health Quarantine, ManZhouLi Customs District, Manzhouli, China;Department of Infectious Diseases Control and Prevention, Chinese People's Liberation Army of China (PLA) Center for Disease Control and Prevention, Beijing, China;Institute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China;Institute of Nuclear, Biological, and Chemical weapons (NBC) Defence, PLA Army, Beijing, China;School of Medicine, Nankai University, Tianjin, China;State Key Laboratory of Emerging Infectious Diseases and Centre of Influenza Research, School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China;The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China;

关键词: ticks;    skin;    patients;    infectome;    metatranscriptomic sequencing;   

DOI  :  10.3389/fcimb.2023.1113992

 received in 2022-12-02, accepted in 2023-02-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionTicks are the most important obligate blood-feeding vectors of human pathogens. With the advance of high-throughput sequencing, more and more bacterial community and virome in tick has been reported, which seems to pose a great threat to people.MethodsA total of 14 skin specimens collected from tick-bite patients with mild to severe symptoms were analyzed through meta-transcriptomic sequencings.ResultsFour bacteria genera were both detected in the skins and ticks, including Pseudomonas, Acinetobacter, Corynebacterium and Propionibacterium, and three tick-associated viruses, Jingmen tick virus (JMTV), Bole tick virus 4 (BLTV4) and Deer tick mononegavirales-like virus (DTMV) were identified in the skin samples. Except of known pathogens such as pathogenic rickettsia, Coxiella burnetii and JMTV, we suggest Roseomonas cervicalis and BLTV4 as potential new agents amplified in the skins and then disseminated into the blood. As early as 1 day after a tick-bite, these pathogens can transmit to skins and at most four ones can co-infect in skins.DiscussionAdvances in sequencing technologies have revealed that the diversity of tick microbiome and virome goes far beyond our previous understanding. This report not only identifies three new potential pathogens in humans but also shows that the skin barrier is vital in preventing horizontal transmissions of tick-associated bacteria or virus communities to the host. It is the first research on patients’ skin infectome after a tick bite and demonstrates that more attention should be paid to the cutaneous response to prevent tick-borne illness.

【 授权许可】

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Copyright © 2023 Zhang, Zheng, Chu, Cui, Wei, Bian, Liu, Yao, Jiang, Huo, Yuan, Li, Zhao, Li, Wang, Wei, Zhu, Chen, Gao, Wang, Ye, Song, Jiang, Lam, Ni and Jia