Effect of epidural spinal cord stimulation on female sexual function after spinal cord injury

Frontiers in Neuroscience

Neuroscience

Uzma Samadani¹  Theoden Netoff²  Ann Parr³  David Darrow⁴  Shea Hocaloski⁵  Matthias Walter⁶  Soshi Samejima⁷  Tiev Miller⁷  Claire Shackleton⁷  Rahul Sachdeva⁷  Andrei Krassioukov⁸  Stacy Elliott⁹ 

[1] Department of Bioinformatics and Computational Biology, University of Minnesota, Minneapolis, MN, United States;Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, United States;Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States;Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States;Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States;Hennepin County Medical Center, Minneapolis, MN, United States;GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, BC, Canada;International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;Department of Urology, University Hospital Basel, University of Basel, Basel, Switzerland;International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada;International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada;GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, BC, Canada;International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, BC, Canada;Department of Psychiatry, Vancouver Coastal Health Authority, Vancouver, BC, Canada;Department of Urologic Sciences, Vancouver Coastal Health Authority, Vancouver, BC, Canada;

关键词: spinal cord injuries;    neuromodulation;    sexual dysfunction;    sexual health;    sexuality;    sexual arousal;    orgasm;   

DOI  :  10.3389/fnins.2023.1155796

 received in 2023-01-31, accepted in 2023-03-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

Sexual dysfunction is a common consequence for women with spinal cord injury (SCI); however, current treatments are ineffective, especially in the under-prioritized population of women with SCI. This case-series, a secondary analysis of the Epidural Stimulation After Neurologic Damage (E-STAND) clinical trial aimed to investigate the effect of epidural spinal cord stimulation (ESCS) on sexual function and distress in women with SCI. Three females, with chronic, thoracic, sensorimotor complete SCI received daily (24 h/day) tonic ESCS for 13 months. Questionnaires, including the Female Sexual Function Index (FSFI) and Female Sexual Distress Scale (FSDS) were collected monthly. There was a 3.2-point (13.2%) mean increase in total FSFI from baseline (24.5 ± 4.1) to post-intervention (27.8 ± 6.6), with a 4.8–50% improvement in the sub-domains of desire, arousal, orgasm and satisfaction. Sexual distress was reduced by 55%, with a mean decrease of 12 points (55.4%) from baseline (21.7 ± 17.2) to post-intervention (9.7 ± 10.8). There was a clinically meaningful change of 14 points in the International Standards for Neurological Classification of Spinal Cord Injury total sensory score from baseline (102 ± 10.5) to post-intervention (116 ± 17.4), without aggravating dyspareunia. ESCS is a promising treatment for sexual dysfunction and distress in women with severe SCI. Developing therapeutic interventions for sexual function is one of the most meaningful recovery targets for people with SCI. Additional large-scale investigations are needed to understand the long-term safety and feasibility of ESCS as a viable therapy for sexual dysfunction.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT03026816, NCT03026816.

【 授权许可】

Unknown   
Copyright © 2023 Shackleton, Samejima, Miller, Sachdeva, Parr, Samadani, Netoff, Hocaloski, Elliott, Walter, Darrow and Krassioukov.