Transdiagnostic association between subjective insomnia and depressive symptoms in major psychiatric disorders

Frontiers in Psychiatry

Psychiatry

Masahiro Suzuki¹  Kaori Saitoh¹  Suguru Nakajima¹  Yoshiyuki Kaneko¹  Nobukuni Fujii¹  Jun Kizuki²  Makoto Uchiyama³  Hiroshi Kadotani⁴  Kenichi Kuriyama⁵  Aoi Kawamura⁵  Takuya Yoshiike⁵  Kentaro Nagao⁵  Naoto Yamada⁶ 

[1] Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan;Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan;Department of Sleep-Wake Disorders, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo, Japan;Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan;Tokyo Adachi Hospital, Tokyo, Japan;Department of Psychiatry, Shiga University of Medical Science, Shiga, Japan;Department of Sleep-Wake Disorders, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo, Japan;Kamibayashi Memorial Hospital, Aichi, Japan;

关键词: insomnia;    depressive symptoms;    sleep;    sleep electroencephalography (EEG);    psychiatric disorders;   

DOI  :  10.3389/fpsyt.2023.1114945

 received in 2022-12-03, accepted in 2023-03-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

In psychiatric disorders, comorbid depressive symptoms are associated with clinically important issues such as reduced quality of life, a poor prognosis, and increased suicide risk. Previous studies have found a close relationship between insomnia and depressive symptoms in major depressive disorder (MDD), and that actively improving insomnia heightens the improvement of depressive symptoms. This study aimed to investigate whether the association between insomnia and depressive symptoms is also found in other psychiatric disorders besides MDD. The subjects were 144 patients with MDD (n = 71), schizophrenia (n = 25), bipolar disorder (n = 22), or anxiety disorders (n = 26). Sleep status was assessed subjectively and objectively using the Athens Insomnia Scale (AIS) and sleep electroencephalography (EEG), respectively. Sleep EEG was performed using a portable EEG device. Depressive symptoms were assessed using the Beck Depression Inventory. Subjective insomnia, as defined by the AIS, was associated with depressive symptoms in all disorders. Moreover, in schizophrenia, a relation between depressive symptoms and insomnia was also found by objective sleep assessment methods using sleep EEG. Our findings suggest that the association between subjective insomnia and depressive symptoms is a transdiagnostic feature in major psychiatric disorders. Further studies are needed to clarify whether therapeutic interventions for comorbid insomnia can improve depressive symptoms in major psychiatric disorders, similar to MDD.

【 授权许可】

Unknown   
Copyright © 2023 Nakajima, Kaneko, Fujii, Kizuki, Saitoh, Nagao, Kawamura, Yoshiike, Kadotani, Yamada, Uchiyama, Kuriyama and Suzuki.