Morpholinyl silicon phthalocyanine nanoparticles with lysosome cell death and two-photon imaging functions for in vitro photodynamic therapy of cancer cells

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Kuizhi Chen¹  Xiuqin Chen¹  Tiantian Zhang¹  Yiru Peng¹  Hongjie Yu¹  Jianling Chen²  Yuyang Li³  Linying Chen³ 

[1] College of Chemistry and Chemical Engineering, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Province Key Laboratory of Polymer Materials, Fujian Normal University, Fuzhou, China;College of Photonic & Electronic Engineering, Fujian Normal University, Fuzhou, China;Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China;

关键词: morpholine;    phthalocyanine;    lysosome target;    two-photon bio-imaging;    photodynamic therapy;   

DOI  :  10.3389/fbioe.2023.1181448

 received in 2023-03-07, accepted in 2023-04-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

The lysosome is an important target for realizing antitumor therapy. Lysosomal cell death exerts significant therapeutic effects on apoptosis and drug-resistance. The development of lysosome-targeting nanoparticles to obtain efficient cancer treatment is challenging. In this article, nanoparticles composed of DSPE@M-SiPc and possessing bright two-photon fluorescence, lysosome targeting ability, and photodynamic therapy multifunctionalities are prepared by encapsulating morpholinyl-substituted silicon phthalocyanine (M-SiPc) with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(poly(ethylene glycol))-2000] (DSPE). Two photon fluorescence bioimaging showed that M-SiPc and DSPE@M-SiPc mainly locate in lysosomes after cellular internalization. Upon irradiation, DSPE@M-SiPc effectively generates reactive oxygen species and damages the function of lysosome, subsequently leading to lysosomal cell death. DSPE@M-SiPc is a promising photosensitizer for cancer treatment.

【 授权许可】

Unknown   
Copyright © 2023 Yu, Chen, Chen, Zhang, Li, Chen, Peng and Chen.