Age-related changes in layer II immature neurons of the murine piriform cortex

Frontiers in Cellular Neuroscience

Neuroscience

Stefano Farioli-Vecchioli¹  Nicole Marchetti¹  Bruno Benedetti²  Sebastien Couillard-Despres²  Chiara La Rosa³  Elena Vergnano³  Marco Ghibaudi⁴  Luca Bonfanti⁴ 

[1] Institute of Biochemistry and Cell Biology, National Research Council, Rome, Italy;Institute of Experimental Neuroregeneration, Paracelsus Medical University, Salzburg, Austria;Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Salzburg, Austria;Austrian Cluster for Tissue Regeneration, Vienna, Austria;Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy;Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy;Department of Veterinary Sciences, University of Turin, Turin, Italy;

关键词: brain plasticity;    cerebral cortex;    piriform cortex;    neurogenesis;    mice;    aging;   

DOI  :  10.3389/fncel.2023.1205173

 received in 2023-04-13, accepted in 2023-07-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

The recent identification of a population of non-newly born, prenatally generated “immature” neurons in the layer II of the piriform cortex (cortical immature neurons, cINs), raises questions concerning their maintenance or depletion through the lifespan. Most forms of brain structural plasticity progressively decline with age, a feature that is particularly prominent in adult neurogenesis, due to stem cell depletion. By contrast, the entire population of the cINs is produced during embryogenesis. Then these cells simply retain immaturity in postnatal and adult stages, until they “awake” to complete their maturation and ultimately integrate into neural circuits. Hence, the question remains open whether the cINs, which are not dependent on stem cell division, might follow a similar pattern of age-related reduction, or in alternative, might leave a reservoir of young, undifferentiated cells in the adult and aging brain. Here, the number and features of cINs were analyzed in the mouse piriform cortex from postnatal to advanced ages, by using immunocytochemistry for the cytoskeletal marker doublecortin. The abundance and stage of maturation of cINs, along with the expression of other markers of maturity/immaturity were investigated. Despite a marked decrease in this neuronal population during juvenile stages, reminiscent of that observed in hippocampal neurogenesis, a small amount of highly immature cINs persisted up to advanced ages. Overall, albeit reducing in number with increasing age, we report that the cINs are present through the entire animal lifespan.

【 授权许可】

Unknown   
Copyright © 2023 Ghibaudi, Marchetti, Vergnano, La Rosa, Benedetti, Couillard-Despres, Farioli-Vecchioli and Bonfanti.