Case Report: Improving Verbal Retrieval Deficits With High Definition Transcranial Direct Current Stimulation Targeting the Pre-Supplementary Motor Area in a Patient With Chronic Traumatic Brain Injury

Frontiers in Neurology

Neurology

John Hart¹  Hsueh-Sheng Chiang²  Michael Kraut³  Scott Shakal⁴  Sven Vanneste⁵ 

[1] Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX, United States;Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX, United States;School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United States;Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States;Texas College of Osteopathic Medicine, The University of North Texas Health Science Center, Fort Worth, TX, United States;Trinity College Dublin, Dublin, Ireland;

关键词: TBI;    verbal retrieval;    HD-tDCS;    EEG;    case report;    verbal fluency;    tDCS;    word finding;   

DOI  :  10.3389/fneur.2021.678518

 received in 2021-03-09, accepted in 2021-06-22,  发布年份 2021

来源: Frontiers

【 摘 要 】

We report a patient who has cognitive sequalae including verbal retrieval deficits after severe traumatic brain injury (TBI). The cortico-caudate-thalamic circuit involving the pre-Supplementary Motor Area (pre-SMA) has been proposed to underlie verbal retrieval functions. We hypothesized that High Definition-transcranial Direct Current Stimulation (HD-tDCS) targeting the pre-SMA would selectively modulate this circuit to remediate verbal retrieval deficits. After the patient underwent 10 sessions of 20 min of 1 mA HD-tDCS targeting the pre-SMA, we documented significant improvements for verbal fluency and naming, and for working memory and executive function tasks that involve the frontal lobes. The effects persisted for up to 14 weeks after completion of HD-tDCS treatment. We also demonstrated normalization of the event-related potentials suggesting modulation of the underlying neural circuit. Our study implicates that region-specific non-invasive brain stimulation, such as HD-tDCS, serves as a potential individualized therapeutic tool to treat cognitive deficits by inducing longer-lasting neuroplasticity even in the chronic phase of TBI.

【 授权许可】

Unknown   
Copyright © 2021 Chiang, Shakal, Vanneste, Kraut and Hart.