Systematical assessment of digit ratio in a female masculinization disease: polycystic ovary syndrome

Frontiers in Endocrinology

Endocrinology

Juan Du¹  Yexing Li²  Ziyi Yang²  Xueqi Yan²  Aiqing Zhu²  Yuteng Wang²  Xueying Gao³  Li Liu⁴  Fang Cheng⁴  Fenghua Li⁵  Wei Liu⁶  Dan Liu⁷  Junli Zhao⁸ 

[1] Center for Reproductive Medicine, Shandong University, Jinan, Shandong, China;Center for Reproductive Medicine, Shandong University, Jinan, Shandong, China;Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China;Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China;Shandong Provincial Clinical Research Center for Reproductive Health, Shandong University, Jinan, Shandong, China;Shandong Technology Innovation Center for Reproductive Health, Shandong University, Jinan, Shandong, China;National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China;Center for Reproductive Medicine, Shandong University, Jinan, Shandong, China;Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China;Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China;Shandong Provincial Clinical Research Center for Reproductive Health, Shandong University, Jinan, Shandong, China;Shandong Technology Innovation Center for Reproductive Health, Shandong University, Jinan, Shandong, China;National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China;Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China;Department of Reproductive Medicine, Yinchuan Maternal and Child Health Hospital, Yinchuan, Ning xia, China;Department of Reproductive Medicine, Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China;Department of Reproductive Surgery, Northwest Women’s and Children’s Hospital, Xi’an, Shanxi, China;Reproductive Medicine Center, Department of Obstetrics and Gynecology, Tang Du Hospital, The Air Force Military Medical University, Xi’an, Shanxi, China;Reproductive Medicine Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China;Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia, China;

关键词: polycystic ovary syndrome;    digit ratio;    prenatal androgen exposure;    hyperandrogenism;    anatomical marker;    sexual dimorphism;   

DOI  :  10.3389/fendo.2023.1146124

 received in 2023-01-17, accepted in 2023-03-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundIn recent years, the right ratio of 2nd and 4th digit length (2D:4D) is regarded as an anatomical marker of prenatal testosterone exposure. Polycystic ovary syndrome (PCOS) is a female masculinized disease and is determined by prenatal testosterone exposure. Whether the ratio in the right hand of PCOS women is reduced or not compared with non-PCOS women is under debate. To further investigate the relationship between PCOS and digit ratio, we systematically measured all the digit ratios.MethodsWe recruited 34 non-PCOS women, 116 PCOS women, and 40 men and systematically measured all the ratios of digit length (2D:3D, 2D:4D, 2D:5D, 3D:4D, 3D:5D, and 4D:5D) of right hands and left hands.ResultsLeft 2D:3D, 2D:4D, and 2D:5D in men were significantly lower than those in non-PCOS women. Significantly lower digit ratios of left 2D:3D and 2D:4D were observed in PCOS compared with non-PCOS women. In the subgroup analysis, the left ratio of digit length in 2D:3D and 2D:5D of the hyperandrogenism subgroup was lower than that of the non-hyperandrogenism subgroup without statistical significance. The logistic regression model of PCOS revealed that 2D:3D, 2D:4D, 2D:5D, and 3D:4D of left hands were statistically related to the diagnosis of PCOS among all the digit ratios.ConclusionNot only 2D:4D but also other digit ratios, such as 2D:3D and 2D:5D, are a marker of prenatal testosterone exposure and may be an anatomical marker of PCOS. The majority of these significant differences included left 2D, with the following order: non-PCOS women > PCOS women > men.

【 授权许可】

Unknown   
Copyright © 2023 Yan, Zhu, Li, Yang, Wang, Liu, Liu, Liu, Li, Du, Cheng, Gao and Zhao