Transcriptional control of embryonic and adult neural progenitor activity

Frontiers in Neuroscience

Neuroscience

Isabel Martinez-Garay¹  Niharika Singh²  Florian A. Siebzehnrubl³ 

[1] Division of Neuroscience, School of Biosciences, Cardiff University, Cardiff, United Kingdom;Division of Neuroscience, School of Biosciences, Cardiff University, Cardiff, United Kingdom;European Cancer Stem Cell Research Institute, Cardiff University School of Biosciences, Cardiff, United Kingdom;European Cancer Stem Cell Research Institute, Cardiff University School of Biosciences, Cardiff, United Kingdom;

关键词: neurogenesis;    transcription factor;    embryonic;    adult;    bHLH;    homeodomain;    forkhead;    Zeb1;   

DOI  :  10.3389/fnins.2023.1217596

 received in 2023-05-05, accepted in 2023-07-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Neural precursors generate neurons in the embryonic brain and in restricted niches of the adult brain in a process called neurogenesis. The precise control of cell proliferation and differentiation in time and space required for neurogenesis depends on sophisticated orchestration of gene transcription in neural precursor cells. Much progress has been made in understanding the transcriptional regulation of neurogenesis, which relies on dose- and context-dependent expression of specific transcription factors that regulate the maintenance and proliferation of neural progenitors, followed by their differentiation into lineage-specified cells. Here, we review some of the most widely studied neurogenic transcription factors in the embryonic cortex and neurogenic niches in the adult brain. We compare functions of these transcription factors in embryonic and adult neurogenesis, highlighting biochemical, developmental, and cell biological properties. Our goal is to present an overview of transcriptional regulation underlying neurogenesis in the developing cerebral cortex and in the adult brain.

【 授权许可】

Unknown   
Copyright © 2023 Singh, Siebzehnrubl and Martinez-Garay.