Physical model of end-diastolic and end-systolic pressure-volume relationships of a heart

Frontiers in Physiology

Physiology

Moritz Kalhöfer-Köchling¹  Yunxiao Zhang¹  Yong Wang¹  Eberhard Bodenschatz² 

[1] Laboratory for Fluid Physics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany;DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany;Laboratory for Fluid Physics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany;DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany;Institute for Dynamics of Complex Systems, University of Göttingen, Göttingen, Germany;Laboratory of Atomic and Solid-State Physics and Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, United States;

关键词: cardiac mechanics;    end-diastolic pressure-volume relationship;    end-systolic pressure-volume relationship;    left ventricle;    physics-based model;   

DOI  :  10.3389/fphys.2023.1195502

 received in 2023-03-28, accepted in 2023-07-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

Left ventricular stiffness and contractility, characterized by the end-diastolic pressure-volume relationship (EDPVR) and the end-systolic pressure-volume relationship (ESPVR), are two important indicators of the performance of the human heart. Although much research has been conducted on EDPVR and ESPVR, no model with physically interpretable parameters combining both relationships has been presented, thereby impairing the understanding of cardiac physiology and pathology. Here, we present a model that evaluates both EDPVR and ESPVR with physical interpretations of the parameters in a unified framework. Our physics-based model fits the available experimental data and in silico results very well and outperforms existing models. With prescribed parameters, the new model is used to predict the pressure-volume relationships of the left ventricle. Our model provides a deeper understanding of cardiac mechanics and thus will have applications in cardiac research and clinical medicine.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Kalhöfer-Köchling, Bodenschatz and Wang.