Mendelian randomization shows depression increases the risk of type 2 diabetes

Frontiers in Genetics

Genetics

Sanghun Lee¹  Sungho Won²  Heejin Jin³ 

[1] Department of Medical Consilience, Graduate School, Dankook University, Yongin-si, Republic of Korea;Department of Public Health Science, Seoul National University and Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea;Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea;

关键词: depression;    type 2 diabetes mellitus;    bipolar disorder;    schizophrenia;    mendelian randomization analysis;    causality;   

DOI  :  10.3389/fgene.2023.1181851

 received in 2023-03-08, accepted in 2023-08-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

Introduction: Type 2 diabetes (T2D) is associated with severe mental illnesses (SMIs), such as schizophrenia, bipolar disorder, and depression. However, causal relationships between SMIs and T2D remain unclear owing to potential bias in observational studies. We aimed to characterize the causal effect of SMI liability on T2D using two-sample Mendelian randomization (MR).Methods: The causality between liability to SMI and T2D was investigated using the inverse-variance weighted (IVW), MREgger, MR-Egger with a simulation extrapolation, weighted median, and the MR pleiotropy residual sum and outlier method. Similarly, we performed additional MR which can detect the reverse causation effect by switching exposure and outcome for T2D liability for SMI. To further consider pleiotropic effects between SMIs, multivariable MR analysis was performed after accounting for the other traits.Results: In the univariable IVW method, depression showed a causal effect on T2D (odds ratio [OR]: 1.128, 95% confidence interval [CI]: 1.024–1.245, p = 0.014). Multinomial MR more strongly supported these results (IVW OR: 1.197, 95% CI: 1.069, 1.340, p = 0.002; MR-Egger OR: 1.198, 95% CI: 1.062, 1.349, p = 0.003). Bidirectional MR showed absence of reversecausality between depression and T2D. However, causal relationship of bipolar and schizophrenia on T2D was not detected.Discussion: Careful attention is needed for patients with depression regarding T2D prevention and treatment.

【 授权许可】

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Copyright © 2023 Jin, Lee and Won.