Interrelations between clinical-psychological features and bone mineral density changes in post-menopausal women undergoing anti-osteoporotic treatment: a two-year follow-up

Frontiers in Endocrinology

Endocrinology

Agostino Gaudio¹  Gabriella Martino²  Federica Bellone²  Giovanni Squadrito²  Francesco Corica²  Nunziata Morabito²  Antonino Catalano²  Carmelo Mario Vicario³  Trine Lund-Jacobsen⁴  Peter Schwarz⁴  Gianluca Lo Coco⁵ 

[1] Department of Clinical and Experimental Medicine, University Hospital of Catania, Catania, Italy;Department of Clinical and Experimental Medicine, University Hospital of Messina, Messina, Italy;Department of Cognitive Sciences, Psychology, Education and Cultural Studies, University of Messina, Messina, Italy;Department of Endocrinology, Centre for Cancer and Organ Diseases, The Copenhagen University Hospital, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark;Department of Psychology, Educational Science and Human Movement- University of Palermo, Palermo, Italy;

关键词: clinical psychology;    anxiety;    depression;    quality of life;    post-menopausal;    osteoporosis;    fracture;    bisphosphonates;   

DOI  :  10.3389/fendo.2023.1151199

 received in 2023-01-25, accepted in 2023-04-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionPsychological features have been bidirectionally associated with osteoporosis, but it is still unclear whether patient’s anxiety fluctuations during the anti-osteoporotic treatment can have an impact on bone mineral density (BMD) variation. The aim of this study was to investigate the interrelations between psychological distress features, such as anxiety, depression, health-related QoL (HRQoL) and bone health in women receiving anti-osteoporotic treatment.Methods192 post-menopausal osteoporotic women were treated with alendronate or risedronate according to the standard procedure. The levels of anxiety, depression, and perceived HRQoL, along with BMD, were assessed at baseline and at a 2-year follow-up.ResultsAt the end of the study, the patients showed a statistically significant increase of both psychic and somatic anxiety (p<0.0001) and exhibited a worsening of depressive symptoms (p<0.0001), whereas HRQoL showed no change. BMD improved and no incident fractures occurred. BMD variation (ΔBMD) at lumbar spine was significantly associated with anxiety levels (r=0.23, p=0.021). Multiple regression analysis showed that both patients’ worsening anxiety levels (β = -0.1283, SE=0.06142, p=0.04) and their treatment adherence (β=0.09, SE=0.02, p=0.0006) were independently associated with ΔBMD.DiscussionThe findings of the current follow-up study suggest that BMD in post-menopausal women undergoing anti-osteoporotic treatment was predicted by treatment adherence and anxiety change over time.

【 授权许可】

Unknown   
Copyright © 2023 Martino, Bellone, Vicario, Gaudio, Corica, Squadrito, Lund-Jacobsen, Schwarz, Lo Coco, Morabito and Catalano