The risk of dementia in multiple sclerosis and neuromyelitis optica spectrum disorder

Frontiers in Neuroscience

Neuroscience

Dong Wook Shin¹  Yohwan Yeo²  Se Young Jung³  Eun Bin Cho⁴  Ju-Hong Min⁵  Hee Jin Kim⁵  Kyungdo Han⁶  Jin-Hyung Jung⁷ 

[1] Department of Family Medicine and Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;Department of Clinical Research Design and Evaluation, Sungkyunkwan University, Seoul, Republic of Korea;Department of Digital Health, Samsung Advanced Institute of Health Science and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea;Center for Wireless and Population Health Systems, University of California San Diego, La Jolla, CA, United States;Department of Family Medicine, College of Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea;Department of Family Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;Department of Digital Healthcare, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;Department of Neurology, College of Medicine, Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, Republic of Korea;Department of Neurology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea;Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea;Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea;Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea;Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea;

关键词: multiple sclerosis;    neuromyelitis optica spectrum disorders;    dementia;    risk;    population;   

DOI  :  10.3389/fnins.2023.1214652

 received in 2023-04-30, accepted in 2023-05-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionCognitive impairment is a common feature of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). However, there is a lack of population-based study of dementia risk in these disorders. In the present study, the risk of dementia in MS and NMOSD patients in Republic of Korea was estimated.MethodsData analyzed in this study were obtained from the Korean National Health Insurance Service (KNHIS) database between January 2010 and December 2017. The study included 1,347 MS patients and 1,460 NMOSD patients ≥40 years of age who had not been diagnosed with dementia within 1 year prior to the index date. Matched controls were selected based on age, sex, and the presence of hypertension, diabetes mellitus, or dyslipidemia.ResultsIn MS and NMOSD patients, the risk of developing any dementia [adjusted hazard ratio (aHR) = 2.34; 95% confidence interval (CI) = 1.84–2.96 and aHR = 2.19; 95% CI = 1.61–3.00, respectively], Alzheimer’s disease [AD; aHR = 2.23; 95% confidence interval (CI) = 1.70–2.91 and aHR = 1.99; 95% CI = 1.38–2.88, respectively], and vascular dementia (aHR = 3.75; 95% CI = 1.91–7.35 and aHR = 3.21; 95% CI = 1.47–7.02, respectively) was higher compared with the matched controls. NMOSD patients had a lower risk of any dementia and AD compared with MS patients after adjusting for age, sex, income, hypertension, diabetes, and dyslipidemia (aHR = 0.67 and 0.62).ConclusionThe risk of dementia increased in MS and NMOSD patients and dementia risk was higher in MS than in NMOSD.

【 授权许可】

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Copyright © 2023 Cho, Jung, Jung, Yeo, Kim, Han, Shin and Min.