Opportunities and challenges related to ferroptosis in glioma and neuroblastoma

Frontiers in Oncology

Oncology

Boyan Li¹  Qingtong Wang¹  Zijie Gao¹  Bowen Feng¹  Hao Xue¹  Gang Li¹  Huizhong Chi¹ 

[1] Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong, China;Shandong Key Laboratory of Brain Function Remodeling, Jinan, Shandong, China;

关键词: ferroptosis;    neuroblastoma;    glioblastoma;    GPX4;    immune;   

DOI  :  10.3389/fonc.2023.1065994

 received in 2022-10-10, accepted in 2023-02-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

A newly identified form of cell death known as ferroptosis is characterized by the peroxidation of lipids in response to iron. Rapid progress in research on ferroptosis in glioma and neuroblastoma has promoted the exploitation of ferroptosis in related therapy. This manuscript provides a review of the findings on ferroptosis-related therapy in glioblastoma and neuroblastoma and outlines the mechanisms involved in ferroptosis in glioma and neuroblastoma. We summarize some recent data on traditional drugs, natural compounds and nanomedicines used as ferroptosis inducers in glioma and neuroblastoma, as well as some bioinformatic analyses of genes involved in ferroptosis. Moreover, we summarize some data on the associations of ferroptosis with the tumor immunotherapy and TMZ drug resistance. Finally, we discuss future directions for ferroptosis research in glioma and neuroblastoma and currently unresolved issues.

【 授权许可】

Unknown   
Copyright © 2023 Chi, Li, Wang, Gao, Feng, Xue and Li