Blood biomarkers of secondary outcomes following concussion: A systematic review

Frontiers in Neurology

Neurology

Tengyi Cai¹  Ella E. K. Swaney¹  Vera Ignjatovic²  Marc L. Seal³ 

[1] Department of Haematology, Murdoch Children's Research Institute, Melbourne, VIC, Australia;Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia;Department of Haematology, Murdoch Children's Research Institute, Melbourne, VIC, Australia;Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia;Institute for Clinical and Translational Research, Johns Hopkins All Children's Hospital, St. Petersburg, FL, United States;Department of Pediatrics, Johns Hopkins University, Baltimore, MD, United States;Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia;Developmental Imaging, Murdoch Children's Research Institute, Melbourne, VIC, Australia;

关键词: concussion;    mild traumatic brain injury;    biomarkers;    secondary outcomes;    systematic review;   

DOI  :  10.3389/fneur.2023.989974

 received in 2022-07-09, accepted in 2023-01-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionBlood biomarkers have been identified as an alternative tool for predicting secondary outcomes following concussion. This systematic review aimed to summarize the literature on blood biomarkers of secondary outcomes following concussion in both pediatric and adult cohorts.MethodsA literature search of Embase, Medline and PubMed was conducted. Two reviewers independently assessed retrieved studies to determine inclusion in systematic review synthesis.ResultsA total of 1771 unique studies were retrieved, 58 of which were included in the final synthesis. S100B, GFAP and tau were identified as being associated with secondary outcomes following concussion. Seventeen percent of studies were performed in a solely pediatric setting.ConclusionsValidation of biomarkers associated with secondary outcomes following concussion have been largely limited by heterogeneous study cohorts and definitions of concussion and mTBI, presenting a hurdle for translation of these markers into clinical practice. Additionally, there was an underrepresentation of studies which investigated pediatric cohorts. Adult markers are not appropriate for children, therefore pediatric specific markers of secondary outcomes following concussion present the biggest gap in this field.

【 授权许可】

Unknown   
Copyright © 2023 Swaney, Cai, Seal and Ignjatovic.