Hypothalamus and amyotrophic lateral sclerosis: potential implications in sleep disorders

Frontiers in Aging Neuroscience

Neuroscience

Alessia Giugno¹  Valentina Gnoni²  Daniele Urso²  Ludovica Tamburrino³  Giancarlo Logroscino³  Marco Filardi³  Stefano Zoccolella⁴ 

[1] Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione “Card. G. Panico,”, Tricase, Italy;Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione “Card. G. Panico,”, Tricase, Italy;Department of Neurosciences, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, United Kingdom;Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione “Card. G. Panico,”, Tricase, Italy;Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari Aldo Moro, Bari, Italy;Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione “Card. G. Panico,”, Tricase, Italy;Neurology Unit, San Paolo Hospital, Azienda Sanitaria Locale (ASL) Bari, Bari, Italy;

关键词: amyotrophic lateral sclerosis;    hypothalamus;    sleep disorders;    circadian rhythm;    neurodegeneration;   

DOI  :  10.3389/fnagi.2023.1193483

 received in 2023-03-24, accepted in 2023-06-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects both motor and non-motor functions, including sleep regulation. Emerging evidence suggests that the hypothalamus, a brain region that plays a critical role in sleep-wake regulation, may be involved in the pathogenesis of ALS-related sleep disturbances. In this review, we have summarized results of studies on sleep disorders in ALS published between 2000 and 2023. Thereafter, we examined possible mechanisms by which hypothalamic dysfunctions may contribute to ALS-related sleep disturbances. Achieving a deeper understanding of the relationship between hypothalamic dysfunction and sleep disturbances in ALS can help improve the overall management of ALS and reduce the burden on patients and their families.

【 授权许可】

Unknown   
Copyright © 2023 Gnoni, Zoccolella, Giugno, Urso, Tamburrino, Filardi and Logroscino.