Relaxin in fibrotic ligament diseases: Its regulatory role and mechanism

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Xinzhi Liang¹  Luhui Zhang¹  Shuai Yuan¹  Dong Guo¹  Denghui Xie²  Qun Zhang³ 

[1] Department of Joint Surgery and Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China;Department of Joint Surgery and Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China;Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Academy of Orthopedics, Guangdong Province, Guangzhou, Guangdong, China;Good Clinical Practice Development, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China;

关键词: relaxin;    fibrosis;    ligament;    TGF-β;    fibroblast;   

DOI  :  10.3389/fcell.2023.1131481

 received in 2022-12-25, accepted in 2023-02-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Fibrotic ligament diseases (FLDs) are diseases caused by the pathological accumulation of periarticular fibrotic tissue, leading to functional disability around joint and poor life quality. Relaxin (RLX) has been reported to be involved in the development of fibrotic lung and liver diseases. Previous studies have shown that RLX can block pro-fibrotic process by reducing the excess extracellular matrix (ECM) formation and accelerating collagen degradation in vitro and in vivo. Recent studies have shown that RLX can attenuate connective tissue fibrosis by suppressing TGF-β/Smads signaling pathways to inhibit the activation of myofibroblasts. However, the specific roles and mechanisms of RLX in FLDs remain unclear. Therefore, in this review, we confirmed the protective effect of RLX in FLDs and summarized its mechanism including cells, key cytokines and signaling pathways involved. In this article, we outline the potential therapeutic role of RLX and look forward to the application of RLX in the clinical translation of FLDs.

【 授权许可】

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Copyright © 2023 Yuan, Guo, Liang, Zhang, Zhang and Xie.