Emerging roles of PHLPP phosphatases in lung cancer

Frontiers in Oncology

Oncology

Meng Chen¹  Haihua Yang¹  Xinhang Xia¹  Xuequan Wang¹  Wenhu Pi¹  Yanli Lan¹  Wei Wang¹  Danyang Cai¹ 

[1] Key Laboratory of Radiation Oncology of Taizhou, Radiation Oncology Institute of Enze Medical Health Academy, Department of Radiation Oncology, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China;

关键词: PHLPP;    lung cancer;    phosphatase substrate;    therapeutic target;    potential effect;   

DOI  :  10.3389/fonc.2023.1216131

 received in 2023-05-03, accepted in 2023-07-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

Pleckstrin homologous domain leucine-rich repeating protein phosphatases (PHLPPs) were originally identified as protein kinase B (Akt) kinase hydrophobic motif specific phosphatases to maintain the cellular homeostasis. With the continuous expansion of PHLPPs research, imbalanced-PHLPPs were mainly found as a tumor suppressor gene of a variety of solid tumors. In this review, we simply described the history and structures of PHLPPs and summarized the recent achievements in emerging roles of PHLPPs in lung cancer by 1) the signaling pathways affected by PHLPPs including Phosphoinositide 3-kinase (PI3K)/AKT, RAS/RAF/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and Protein kinase C (PKC) signaling cascades. 2) function of PHLPPs regulatory factor USP46 and miR-190/miR-215, 3) the potential roles of PHLPPs in disease prognosis, Epidermal growth factor receptors (EGFR)- tyrosine kinase inhibitor (TKI) resistance and DNA damage, 4) and the possible function of PHLPPs in radiotherapy, ferroptosis and inflammation response. Therefore, PHLPPs can be considered as either biomarker or prognostic marker for lung cancer treatment.

【 授权许可】

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Copyright © 2023 Xia, Pi, Chen, Wang, Cai, Wang, Lan and Yang