Diaphragmatic ultrasound and patent ductus arteriosus in the newborn: A retrospective case series

Frontiers in Pediatrics

Pediatrics

Mahesh Nanjundappa¹  Theodore Dassios²  Aaron J. Bell³  Emma Williams⁴  Anne Greenough⁴  Fahad M. S. Arattu Thodika⁴ 

[1]Neonatal Intensive Care Centre, King's College Hospital NHS Foundation Trust, London, United Kingdom

[2]Neonatal Intensive Care Centre, King's College Hospital NHS Foundation Trust, London, United Kingdom

[3]Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom

[4]Paediatric Cardiology, Guy's and St Thomas’ Hospitals NHS Trust, London, United Kingdom

[5]Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom

关键词: diaphragmatic ultrasound;    mean inspiratory velocity;    prematurity;    patent ductal arteriosus;    infant;   

DOI  :  10.3389/fped.2023.1123939

 received in 2022-12-14, accepted in 2023-02-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundPatent ductus arteriosus (PDA) and diaphragmatic dysfunction are frequently seen in newborn infants but their relationship remains unknown. We aimed to use point of care ultrasound to compare diaphragmatic kinetics in infants with a PDA compared to in those without a PDA.MethodsM-mode ultrasonography was used to measure the mean inspiratory velocity (VI) in newborn infants with and without a haemodynamically significant PDA admitted in the Neonatal Unit at King's College Hospital during a three month period.ResultsSeventeen diaphragmatic ultrasound studies were reviewed from 14 infants with a median (IQR) gestational age of 26.1 (25.8–30.6) weeks, birth weight of 780 (660–1385) gr at a postnatal age of 18 (14–34) days. Eight scans had evidence of a PDA. The median (IQR) VI was significantly lower in scans with a PDA [1.01 (0.78–1.86) cm/s] compared to the ones without a PDA [3.21 (2.80–3.59) cm/s, p < 0.001]. The median (IQR) gestational age was lower in infants with a PDA [25.8 (25.6–27.3) weeks] compared to infants without a PDA [29.0 (26.1–35.1) weeks, p = 0.007]. Using multivariable linear regression analysis the VI was independently associated with a PDA (adjusted p < 0.001) but not with the gestational age (adjusted p = 0.659).ConclusionsPatent ductus arteriosus was associated with a lower mean inspiratory velocity in neonates and this effect was independent of gestational age.

【 授权许可】

Unknown   
© 2023 Dassios, Arattu Thodika, Nanjundappa, Williams, Bell and Greenough.