Association between body mass index and treatment completion in extended-release naltrexone-treated patients with opioid dependence

Frontiers in Psychiatry

Psychiatry

Igor Elman¹  Corinde E. Wiers²  Daniel D. Langleben²  Xinyi Li²  Zhenhao Shi²  Kevin G. Lynch²  Gene-Jack Wang³ 

[1] Department of Psychiatry, Cambridge Health Alliance, Harvard Medical School, Boston, MA, United States;Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States;National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States;

关键词: opioid use disorder;    medication-assisted treatment;    body weight gain;    addiction;    food;    obesity;    eating;   

DOI  :  10.3389/fpsyt.2023.1247961

 received in 2023-06-26, accepted in 2023-07-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundExcessive consumption of opioids is associated with impaired metabolic function including increased body mass index (BMI). Opioid antagonist naltrexone (NTX) is an effective treatment for opioid use disorder (OUD) that has the potential to mitigate such metabolic disturbances. Understanding the relationship between treatment adherence and BMI in NTX-treated OUD patients may provide valuable insights into optimizing clinical outcomes.MethodsPatients with opioid dependence were offered up to three monthly injections of extended-release (XR) NTX. Treatment completers (n = 41) were defined as those who had received all three XR-NTX injections, and non-completers (n = 20) as those missing at least one injection. Logistic regression was performed to examine the association between pre-treatment BMI and treatment completion.ResultsBMI was positively associated with treatment completion. This association remained significant after adjusting for potentially confounding variables.ConclusionOur findings suggest that baseline BMI may serve as a potential predictor of XR-NTX treatment adherence in patients with OUD and could help healthcare providers and policy makers alike in developing strategies to improve retention and tailor interventions for specific patient subgroups.

【 授权许可】

Unknown   
Copyright © 2023 Li, Langleben, Lynch, Wang, Elman, Wiers and Shi.