Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis

Frontiers in Endocrinology

Endocrinology

Song Quan¹  Xiao Shi¹  Meiqi Ren¹  Liantong Wang¹  Jinghua Chen²  Liqin Wen² 

[1] Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, NanFang Hospital, Southern Medical University, Guangzhou, China;The First School of Clinical Medicine, Southern Medical University, Guangzhou, China;

关键词: recurrent pregnancy loss;    spontaneous abortion;    endocrine dysfunction;    zinc;    copper;    lead;    cadmium;   

DOI  :  10.3389/fendo.2023.1216507

 received in 2023-05-04, accepted in 2023-07-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveThis study aimed to evaluate the association between blood heavy metal (zinc (Zn), copper (Cu), lead (Pb), and cadmium (Cd)) concentrations and spontaneous abortion (SA) and recurrent pregnancy loss (RPL) and explore the possible endocrine dysfunction associated with it.MethodsA literature search was performed in the PubMed, Embase, Cochrane Library, and Web of Science databases up to April 2023. The overall effects were expressed as the standard mean difference (SMD). Subgroup analysis was performed according to the type of abortion (SA or RPL). Stata 16.0 was utilized for data analysis.ResultsBased on the integrated findings, abortion women showed significantly lower Zn (SMD = −1.05, 95% CI: −1.74 to −0.36, p = 0.003) and Cu concentrations (SMD = −1.42, 95% CI: −1.97 to −0.87, p <0.001) and higher Pb (SMD = 1.47, 95% CI: 0.89–2.05, p <0.001) and Cd concentrations (SMD = 1.15, 95% CI: 0.45–1.85, p = 0.001) than normal pregnant women. Subgroup analysis showed that Zn and Cu deficiency and Cd and Pb exposure were significantly (p <0.05) associated with RPL, whereas Cu deficiency and Cd and Pb exposure were significantly (p <0.05) associated with SA.ConclusionZn and Cu deficiencies and Pb and Cd exposure were associated with abortion. Endocrine dysfunction, such as insulin resistance, vitamin D insufficiency, and abnormal thyroid and sex hormone concentrations, is thought to be involved in heavy metal-related abortion.

【 授权许可】

Unknown   
Copyright © 2023 Ren, Wang, Wen, Chen, Quan and Shi