Early-life exposure to di (2-ethyl-hexyl) phthalate: Role in children with endocrine disorders

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Fang Deng¹  Luodan Zhang¹  Shuiping Lou²  Fa Zeng² 

[1] Department of Nephrology, Anhui Provincial Children’s Hospital, Children’s Hospital of Anhui Medical University, Hefei, China;Shenzhen Longhua Maternity and Child Healthcare Hospital, Shenzhen, China;

关键词: di (2-ethyl-hexyl) phthalate (DEHP);    endocrine-disrupting chemicals (EDCs);    early-life;    placenta;    offspring;    lipid and glucose;   

DOI  :  10.3389/fcell.2023.1115229

 received in 2022-12-03, accepted in 2023-02-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Di (2-ethyl-hexyl) phthalate (DEHP), one of endocrine-disrupting chemicals (EDCs), has widespread concern due to its serious health hazards. Exposure to DEHP in the early stage of life affects fetal metabolic and endocrine function, which even would cause genetic lesions. To date, it is widely believed that the increasing incidence of childhood obesity and diabetes in adolescents is related to the impact of DEHP on glucose and lipid homeostasis in children. However, there remains a knowledge gap to recognize these adverse effects. Thus, in this review, besides the exposure routes and levels of DEHP, we further outline the effects of early-life exposure to DEHP on children and potential mechanisms, focusing on the aspect of metabolic and endocrine homeostasis.

【 授权许可】

Unknown   
Copyright © 2023 Zeng, Zhang, Deng and Lou.