Attention, attention! Posttraumatic stress disorder is associated with altered attention-related brain function

Frontiers in Behavioral Neuroscience

Neuroscience

Clara G. Zundel¹  Amanpreet Bhogal¹  MacKenna Shampine¹  Carmen Carpenter¹  Leah C. Gowatch¹  Julia M. Evanski²  Samantha L. Ely³  Hilary Marusak⁴ 

[1] Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States;Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States;Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, United States;Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States;Translational Neuroscience PhD Program, Wayne State University School of Medicine, Detroit, MI, United States;Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States;Translational Neuroscience PhD Program, Wayne State University School of Medicine, Detroit, MI, United States;Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, United States;Merrill Palmer Skillman Institute, Wayne State University, Detroit, MI, United States;

关键词: posttraumatic stress;    attention network;    veterans;    trauma;    resting-state;    continuous performance task;    functional magnetic resonance imaging;    neuroimaging;   

DOI  :  10.3389/fnbeh.2023.1244685

 received in 2023-06-22, accepted in 2023-08-01,  发布年份 2023

来源: Frontiers

【 摘 要 】

Posttraumatic stress disorder (PTSD) is a debilitating condition characterized by altered arousal, mood, and cognition. Studies report attentional alterations such as threat bias in individuals with PTSD, though this work has largely been conducted within emotionally-charged contexts (e.g., threatening stimuli). Emerging behavioral evidence suggests that PTSD-related attention deficits exist even in the absence of threatening cues or anxiety triggers. However, the role and functioning of attention brain circuits as they relate to PTSD remains underexplored. In this mini review, we highlight recent work using non-emotional stimuli to investigate the neurobiology of attention and disruptions to attention-related brain function among individuals with PTSD. We then discuss gaps in the current literature, including questions pertaining to the neural circuitry of attentional alterations in PTSD, as well as the contributions that trauma exposure, PTSD symptoms, comorbidities, and pre-existing vulnerabilities may have in this relationship. Finally, we suggest future directions for this emerging area of research, which may further inform knowledge surrounding the neurobiological underpinnings of PTSD and potential treatments.

【 授权许可】

Unknown   
Copyright © 2023 Ely, Zundel, Gowatch, Evanski, Bhogal, Carpenter, Shampine and Marusak.