Design, fabrication, and preclinical testing of a miniaturized, multispectral, chip-on-tip, imaging probe for intraluminal fluorescence imaging of the gastrointestinal tract

Frontiers in Photonics

Photonics

Bridget Slomka¹  Thomas G. Knapp¹  Travis W. Sawyer²  Suzann Duan³  Ricky Sontz³  Juanita L. Merchant³  Natzem Lima⁴ 

[1] Department of Biomedical Engineering, College of Engineering, University of Arizona, Tucson, AZ, United States;Department of Biomedical Engineering, College of Engineering, University of Arizona, Tucson, AZ, United States;Wyant College of Optical Sciences, University of Arizona, Tucson, AZ, United States;Department of Medicine, College of Medicine Tucson, University of Arizona, Tucson, AZ, United States;Wyant College of Optical Sciences, University of Arizona, Tucson, AZ, United States;

关键词: endoscopy;    oncology;    cancer;    fluorescence;    miniature imaging;    multispectral imaging;    chip-on-tip;   

DOI  :  10.3389/fphot.2022.1067651

 received in 2022-10-12, accepted in 2022-12-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Gastrointestinal cancers continue to account for a disproportionately large percentage of annual cancer deaths in the United States. Advancements in miniature imaging technology combined with a need for precise and thorough tumor detection in gastrointestinal cancer screenings fuel the demand for new, small-scale, and low-cost methods of localization and margin identification with improved accuracy. Here, we report the development of a miniaturized, chip-on-tip, multispectral, fluorescence imaging probe designed for compatibility with a gastroscope working channel with the aim of detecting cancerous lesions in point-of-care endoscopy of the gastrointestinal lumen. Preclinical testing has confirmed fluorescence sensitivity and supports that this miniature probe can locate structures of interest via detection of fluorescence emission from exogenous contrast agents. This work demonstrates the design and preliminary performance evaluation of a miniaturized, single-use, chip-on-tip fluorescence imaging system, capable of detecting multiplexed fluorophores, and devised for deployment via the accessory channel of a standard gastroscope.

【 授权许可】

Unknown   
Copyright © 2023 Slomka, Duan, Knapp, Lima, Sontz, Merchant and Sawyer.