Occurrence of extended- spectrum β-lactamase harboring K. pneumoniae in various sources: a one health perspective

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Yahong Liu¹  Liang-xing Fang¹  Nafeesa Yasmeen¹  Zulqarnain Baloch²  Bilal Aslam³ 

[1]College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

[2]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China

[3]Institute of Microbiology, Government College University, Faisalabad, Pakistan

关键词: K. pneumonia;    extended spectrum beta-lactamases;    prevalence;    one health;    Pakistan;   

DOI  :  10.3389/fcimb.2023.1103319

 received in 2022-11-20, accepted in 2023-05-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

This study was designed to investigate the occurrence and dissemination of extended-spectrum β-lactamase (ESBL) harboring Klebsiella pneumoniae in various ecological niches under the one health approach. A total of 793 samples were collected from animals, humans, and the environment. The findings of the study revealed the occurrence of K. pneumoniae as follows: animals (11.6%), humans (8.4%), and associated environments (7.0%), respectively. A high occurrence rate of ESBL genes was found in animals compared to human and environmental isolates. A total of 18 distinct sequence types (STs) and 12 clonal complexes of K. pneumoniae were observed. Overall, six STs of K. pneumoniae were identified in commercial chickens, and three were found in rural poultry. The majority of K. pneumoniae STs found in this study were positive for blaSHV, while the positivity of other ESBL-encoding genes combinations was different in different STs. The high occurrence rate of ESBL-harboring K. pneumoniae found in animals as compared to other sources is alarming and has the potential to be disseminated to the associated environment and community.

【 授权许可】

Unknown   
Copyright © 2023 Yasmeen, Aslam, Fang, Baloch and Liu