Motivational disturbances in rodent models of neuropsychiatric disorders

Frontiers in Behavioral Neuroscience

Neuroscience

Tara Canonica¹  Ioannis Zalachoras¹ 

[1] null;

关键词: motivation;    depression;    stress;    schizophrenia;    parkinson’s disease;    operant conditioning;    dopamine;   

DOI  :  10.3389/fnbeh.2022.940672

 received in 2022-05-10, accepted in 2022-07-26,  发布年份 2022

来源: Frontiers

【 摘 要 】

Motivated behavior is integral to the survival of individuals, continuously directing actions toward rewards or away from punishments. The orchestration of motivated behavior depends on interactions among different brain circuits, primarily within the dopaminergic system, that subserve the analysis of factors such as the effort necessary for obtaining the reward and the desirability of the reward. Impairments in motivated behavior accompany a wide range of neuropsychiatric disorders, decreasing the patients’ quality of life. Despite its importance, motivation is often overlooked as a parameter in neuropsychiatric disorders. Here, we review motivational impairments in rodent models of schizophrenia, depression, and Parkinson’s disease, focusing on studies investigating effort-related behavior in operant conditioning tasks and on pharmacological interventions targeting the dopaminergic system. Similar motivational disturbances accompany these conditions, suggesting that treatments aimed at ameliorating motivation levels may be beneficial for various neuropsychiatric disorders.

【 授权许可】

Unknown   
Copyright © 2022 Canonica and Zalachoras.