Associations of aortic stiffness and intra-aortic flow parameters with epicardial adipose tissue in patients with type-2 diabetes

Frontiers in Clinical Diabetes and Healthcare

Clinical Diabetes and Healthcare

Eléonore Blondiaux¹  Toan Nguyen¹  Valéria Della Valle¹  Mikaël Prigent²  Mohamed Zarai²  Fabrizio Andreelli³  Emilie Bollache⁴  Thomas Dietenbeck⁴  Nadjia Kachenoura⁴  Khaoula Bouazizi⁴  Alban Redheuil⁵  Judith Aron-Wisnewsky⁶  Karine Clément⁶  Abdallah Noufaily⁷ 

[1] Assistance Publique Hôpitaux de Paris, Radiology Department, Armand-Trousseau Hospital, Paris, France;ICAN Imaging, Institute of Cardiometabolism and Nutrition (ICAN), Paris, France;ICAN Imaging, Institute of Cardiometabolism and Nutrition (ICAN), Paris, France;Assistance Publique Hôpitaux de Paris, Diabetology Department, Pitié-Salpêtrière Hospital, Paris, France;Laboratoire d’Imagerie Biomédicale (LIB), Sorbonne Université, Institut National de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Paris, France;ICAN Imaging, Institute of Cardiometabolism and Nutrition (ICAN), Paris, France;Laboratoire d’Imagerie Biomédicale (LIB), Sorbonne Université, Institut National de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Paris, France;ICAN Imaging, Institute of Cardiometabolism and Nutrition (ICAN), Paris, France;Unité d’Imagerie Cardiovasculaire et Thoracique (ICT), Pitié-Salpêtrière Hospital, Paris, France;Sorbonne Université, INSERM, Nutrition and Obesities; approches systémiques (NutriOmique), Pitié-Salpêtrière Hospital, Nutrition Department, Paris, France;Assistance Publique Hôpitaux de Paris, Nutrition Department, Centre de Recherche en Nutrition Humaine (CRNH) Ile-de-France, Pitié-Salpêtrière Hospital, Paris, France;Unité d’Imagerie Cardiovasculaire et Thoracique (ICT), Pitié-Salpêtrière Hospital, Paris, France;

关键词: epicardiac adipose tissue;    cardiovascular MRI;    type 2 diabetes;    aortic flow;    cardiometabolic disease;   

DOI  :  10.3389/fcdhc.2023.1106342

 received in 2022-11-25, accepted in 2023-05-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundIt has been shown that increased aortic stiffness is related to type-2 diabetes (T2D) which is considered as a risk factor for cardiovascular disease. Among other risk factors is epicardial adipose tissue (EAT) which is increased in T2D and is a relevant biomarker of metabolic severity and adverse outcome.PurposeTo assess aortic flow parameters in T2D patients as compared to healthy individuals and to evaluate their associations with EAT accumulation as an index of cardiometabolic severity in T2D patients.Materials and methodsThirty-six T2D patients as well as 29 healthy controls matched by age and sex were included in this study. Participants had cardiac and aortic MRI exams at 1.5 T. Imaging sequences included cine SSFP for left ventricle (LV) function and EAT assessment and aortic cine and phase-contrast imaging for strain and flow parameters quantification.ResultsIn this study, we found LV phenotype to be characterized by concentric remodeling with decreased stroke volume index despite global LV mass within a normal range. EAT was increased in T2D patients compared to controls (p<0.0001). Moreover, EAT, a biomarker of metabolic severity, was negatively correlated to ascending aortic (AA) distensibility (p=0.048) and positively to the normalized backward flow volume (p=0.001). These relationships remained significant after further adjustment for age, sex and central mean blood pressure. In a multivariate model, presence/absence of T2D and AA normalized backward flow (BF) to forward flow (FF) volumes ratio are both significant and independent correlates of EAT.ConclusionIn our study, aortic stiffness as depicted by an increased backward flow volume and decreased distensibility seems to be related to EAT volume in T2D patients. This observation should be confirmed in the future on a larger population while considering additional biomarkers specific to inflammation and using a longitudinal prospective study design.

【 授权许可】

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Copyright © 2023 Bouazizi, Zarai, Noufaily, Prigent, Dietenbeck, Bollache, Nguyen, Della Valle, Blondiaux, Clément, Aron-Wisnewsky, Andreelli, Redheuil and Kachenoura