Ferroptosis is a new therapeutic target for spinal cord injury

Frontiers in Neuroscience

Neuroscience

Hui-Lin Xi¹  Meng-Ze He¹  Die Zhang¹  Zhi-Zhong Deng¹  Qing-Yan Wang¹  Xin-Yue Bai¹  Xiao-Long Liu¹  Dong-Min Wei¹  Yan-Ling Yang² 

[1] School of Medicine, Yan’an University, Yan’an, China;null;

关键词: spinal cord injury;    Ferroptosis;    Ferroptosis inhibitors;    clinical translation;    animal models;   

DOI  :  10.3389/fnins.2023.1136143

 received in 2023-01-02, accepted in 2023-02-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

Spinal cord injury is a serious traumatic disease. As Ferroptosis has been increasingly studied in recent years, it has been found to be closely related to the pathophysiological processes of spinal cord injury. Iron overload, reactive oxygen species accumulation, lipid peroxidation and glutamate accumulation associated with Ferroptosis are all present in spinal cord injury, and thus Ferroptosis is thought to be involved in the pathological processes secondary to spinal cord injury. This article highlights the relationship between Ferroptosis and spinal cord injury, lists substances that improve spinal cord injury by inhibiting Ferroptosis, and concludes with a discussion of the problems that may be encountered in the clinical translation of Ferroptosis inhibitors as a means of enabling their faster use in clinical treatment.

【 授权许可】

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Copyright © 2023 Bai, Liu, Deng, Wei, Zhang, Xi, Wang, He and Yang.