Multi-b-value diffusion stretched-exponential model parameters correlate with MIB-1 and CD34 expression in Glioma patients, an intraoperative MR-navigated, biopsy-based histopathologic study

Frontiers in Oncology

Oncology

Yong Zhang¹  Haixia Cheng²  Tianming Qiu³  Xuefei Dang⁴  Zhenwei Yao⁵  Junlong Wang⁵  Yan Ren⁵  Wenting Rui⁵  Jing Wang⁵  Hanqiu Liu⁵  Hua Zhang⁶  Haopeng Pang⁷ 

[1] Department of Magnetic Resonance Research, General Electric Healthcare, Shanghai, China;Department of Neuropathology, Huashan Hospital, Fudan University, Shanghai, China;Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China;Department of Oncology, Minhang Branch of Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China;Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China;Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China;Minimally Invasive Therapy Center, Shanghai Cancer Center, Fudan University, Shanghai, China;Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China;

关键词: glioma;    diffusion magnetic resonance imaging;    stretched exponential model;    biopsy;    intraoperative navigation;   

DOI  :  10.3389/fonc.2023.1104610

 received in 2022-11-23, accepted in 2023-04-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundTo understand the pathological correlations of multi-b-value diffusion-weighted imaging (MDWI) stretched-exponential model (SEM) parameters of α and diffusion distribution index (DDC) in patients with glioma. SEM parameters, as promising biomarkers, played an important role in histologically grading gliomas.MethodsBiopsy specimens were grouped as high-grade glioma (HGG) or low-grade glioma (LGG). MDWI-SEM parametric mapping of DDC1500, α1500 fitted by 15 b-values (0-1,500 sec/mm2)and DDC5000 and α5000 fitted by 22 b-values (0-5,000 sec/mm2) were matched with pathological samples (stained by MIB-1 and CD34) by coregistered localized biopsies, and all SEM parameters were correlated with these pathological indices pMIB-1(percentage of MIB-1 expression positive rate) and CD34-MVD (CD34 expression positive microvascular density for each specimen). The two-tailed Spearman’s correlation was calculated for pathological indexes and SEM parameters, as well as WHO grades and SEM parameters.ResultsMDWI-derived α1500 negatively correlated with CD34-MVD in both LGG (6 specimens) and HGG (26 specimens) (r=-0.437, P =0.012). MDWI-derived DDC1500 and DDC5000 negatively correlated with MIB-1 expression in all glioma patients (P<0.05). WHO grades negatively correlated with α1500(r=-0.485; P=0.005) and α5000(r=-0.395; P=0.025).ConclusionsSEM-derived DDC and α are significant in histologically grading gliomas, DDC may indicate the proliferative ability, and CD34 stained microvascular perfusion may be an important determinant of water diffusion inhomogeneity α in glioma.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Zhang, Dang, Rui, Cheng, Wang, Zhang, Qiu, Yao, Liu, Pang and Ren