The clinicopathological analysis of ocular and orbit tumors in southeast of China

Frontiers in Oncology

Oncology

Ke Shi¹  Huping Wu¹  Zhiwen Xie¹  Yuan Lin¹  Xie Fang¹  Yanlin Zhong¹  Minqing Cai¹  Xiaodong Liu¹  Yujie Zhang¹  Shangkun Ou¹  Shengqi Su² 

[1] Eye Institute of Xiamen University and affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China;Fujian Provincial Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China;Eye Institute of Xiamen University and affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China;Fujian Provincial Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China;Xiamen Science and Technology Middle School, Xiamen, Fujian, China;

关键词: ocular tumor;    benign tumor;    malignant tumor;    clinicopathologic characteristics;    Southeast of China;   

DOI  :  10.3389/fonc.2023.1118862

 received in 2022-12-08, accepted in 2023-04-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

PurposeThe purpose of this study is to describe the clinicopathologic characteristics of ocular surface and orbit tumors in the Southeast of China and explore the method to differentiate the benign and malignant masses.Materials and methods3468 patients undergoing mass resection from January 2015 to December 2020 were selected as observation subjects and were classified into benign and malignant masses according to postoperative pathology. The clinicopathologic characteristics were collected, including gender, age, pathological tissue signs, and pathological signs. Multivariate Logistic regression analysis of independent risk factors of malignant mass was applied to establish a diagnostic model and the efficacy was evaluated by the subject working characteristics (ROC) curve.ResultsBenign tumors accounted for 91.5% of all cases, and malignant tumors accounted for 8.5%. The most common ocular benign tumors were nevi (24.2%), granuloma (17.1%), and cysts (16.4%). The most common ocular malignant tumors were malignant lymphoma (32.1%) and Basal cell carcinoma (20.2%). As for the histologic origin, melanocytic origin was on the list with 819 (23.6%), mesenchymal 661 (19.1%), epithelial 568 (16.3%), cystic 521 (15.0%), skin adnexal 110 (3.1%), lymphoid 94 (2.8%), and Neural 25(0.8%). Based on the gender, age, tumor location, and the pathological tissue image feature (including differentiation, structural atypia, covering epithelial, keratosis, nest structure/distribution, nuclear atypia, cytoplasmic change and nuclear division), the diagnostic model had predictive value to differentiate the benign and malignant masses.ConclusionMost ocular surface and orbit tumors are benign. Tumor diagnosis is relative to the patient’s age, gender, tumor location, and pathologic characteristics. We generated a satisfactory diagnostic model to differential diagnosis of benign and malignant masses.

【 授权许可】

Unknown   
Copyright © 2023 Lin, Liu, Zhang, Xie, Fang, Shi, Zhong, Su, Cai, Wu and Ou