Anesthesia and analgesia for experimental craniotomy in mice and rats: a systematic scoping review comparing the years 2009 and 2019

Frontiers in Neuroscience

Neuroscience

Marion Bankstahl¹  Cathalijn Leenaars¹  André Bleich¹  Aylina Glasenapp¹  Helen Stirling²  Nina Miljanovic²  Katharina Schönhoff²  Katharina Aulehner²  Vanessa Philippi²  Verena Buchecker²  Hannah King²  Lara von Schumann²  Heidrun Potschka²  Maria Reiber²  Paulin Jirkof³ 

[1] Hannover Medical School, Institute for Laboratory Animal Science, Hanover, Germany;Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilian University of Munich, Munich, Germany;Office for Animal Welfare and 3Rs, University of Zurich, Zurich, Switzerland;

关键词: neuroscience;    multimodal analgesia;    pain;    animal welfare;    refinement;    surgery;    postoperative pain;    neurosurgery;   

DOI  :  10.3389/fnins.2023.1143109

 received in 2023-01-12, accepted in 2023-03-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

Experimental craniotomies are a common surgical procedure in neuroscience. Because inadequate analgesia appears to be a problem in animal-based research, we conducted this review and collected information on management of craniotomy-associated pain in laboratory mice and rats. A comprehensive search and screening resulted in the identification of 2235 studies, published in 2009 and 2019, describing craniotomy in mice and/or rats. While key features were extracted from all studies, detailed information was extracted from a random subset of 100 studies/year. Reporting of perioperative analgesia increased from 2009 to 2019. However, the majority of studies from both years did not report pharmacologic pain management. Moreover, reporting of multimodal treatments remained at a low level, and monotherapeutic approaches were more common. Among drug groups, reporting of pre- and postoperative administration of non-steroidal anti-inflammatory drugs, opioids, and local anesthetics in 2019 exceeded that of 2009. In summary, these results suggest that inadequate analgesia and oligoanalgesia are persistent issues associated with experimental intracranial surgery. This underscores the need for intensified training of those working with laboratory rodents subjected to craniotomies.Systematic review registrationhttps://osf.io/7d4qe.

【 授权许可】

Unknown   
Copyright © 2023 King, Reiber, Philippi, Stirling, Aulehner, Bankstahl, Bleich, Buchecker, Glasenapp, Jirkof, Miljanovic, Schönhoff, von Schumann, Leenaars and Potschka.