Artemisitene Alters LPS-Induced Oxidative stress, inflammation and Ferroptosis in Liver Through Nrf2/HO-1 and NF-kB Pathway

Frontiers in Pharmacology

Pharmacology

Congshu Xiao¹  Jianxin Bai¹  Songqiao Feng¹  Changzhi Zhao² 

[1] Second Affiliated Hospital of Dalian Medical University, Dalian, China;Second Affiliated Hospital of Dalian Medical University, Dalian, China;Dalian Municipal Friendship Hospital, Dalian, China;

关键词: liver sepsis;    ferroptosis;    Nrf2;    artemisitene;    NF-κB;   

DOI  :  10.3389/fphar.2023.1177542

 received in 2023-03-01, accepted in 2023-04-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

The liver plays a critical role in sepsis, which is a serious worldwide public health problem. A novel mechanism of controlled cell death called ferroptosis has recently been described. Disrupted redox equilibrium, excessive iron, and enhanced lipid peroxidation are key features of ferroptosis. It is unknown how ferroptosis affects liver damage caused by sepsis. In the present study, we aimed to elucidate the pathways and explore the impact of artemisitene (ATT) on ferroptosis in sepsis-induced liver injury. Our findings demonstrated that ATT significantly decreased liver damage and ferroptotic characteristics. Additionally, ATT significantly reduced the expression of the nuclear factor-κB (NF-κB) subunit to reduce LPS-induced hepatic oxidative stress and inflammation and upregulated the expression of nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2) and its downstream protein heme oxygenase 1 (HO-1). This may offer a new strategy for preventing LPS-induced hepatic injury.

【 授权许可】

Unknown   
Copyright © 2023 Zhao, Xiao, Feng and Bai.