Metabolic regulation of dendritic cell activation and immune function during inflammation

Frontiers in Immunology

Immunology

Lijia Guo¹  Yiyang Jiang²  Yi Liu²  Yingyi Chen²  Lili Wu²  Junji Xu²  Zhenhua Luo²  Ziqi Yan²  Juan Du² 

[1] Department of Orthodontics School of Stomatology, Capital Medical University, Beijing, China;Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China;Immunology Research Center for Oral and Systemic Health, Beijing Friendship Hospital, Capital Medical University, Beijing, China;

关键词: metabolic reprogramming;    glycolysis;    inflammation;    dendritic cells (DC);    cellular metabolism;   

DOI  :  10.3389/fimmu.2023.1140749

 received in 2023-01-09, accepted in 2023-02-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

Dendritic cells (DCs) are antigen-presenting cells that bridge innate and adaptive immune responses. Multiple cell types, including DCs, rely on cellular metabolism to determine their fate. DCs substantially alter cellular metabolic pathways during activation, such as oxidative phosphorylation, glycolysis, fatty acid and amino acid metabolism, which have crucial implications for their functionality. In this review, we summarize and discuss recent progress in DC metabolic studies, focusing on how metabolic reprogramming influences DC activation and functionality and the potential metabolic differences among DC subsets. Improving the understanding of the relationship between DC biology and metabolic regulation may provide promising therapeutic targets for immune-mediated inflammatory diseases.

【 授权许可】

Unknown   
Copyright © 2023 Wu, Yan, Jiang, Chen, Du, Guo, Xu, Luo and Liu