Effect and possible mechanisms of saponins in Chinese herbal medicine exerts for the treatment of myocardial ischemia-reperfusion injury in experimental animal: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Li Tian¹  Jiarong Fan¹  Xinye Li¹  Can Liu²  Fan Yang²  Yanwei Xing²  Xin Su³  Jiahao Sun⁴ 

[1] Clinical Department of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China;Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China;Sun Yat-sen University Cancer Center, Guangzhou, China;Yanqing Hospital of Beijing Chinese Medicine Hospital, Beijing, China;

关键词: meta-analysis;    saponins;    traditional Chinese medicine;    myocardial ischemia-reperfusion injury;    experimental animal model;    infarct size;    cardiac function;   

DOI  :  10.3389/fcvm.2023.1147740

 received in 2023-01-19, accepted in 2023-07-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionPreventing ischemia-reperfusion injury is the main direction of myocardial infarction treatment in the convalescent stage. Some studies have suggested that saponins in Traditional Chinese medicine (TCM) preparations can protect the myocardium by various mechanisms. Our meta-analysis aims to evaluate the efficacy of TCM saponins in treating myocardial ischemia-reperfusion injury (MIRI) and to summarize the potential molecular mechanisms further.MethodsWe conducted a literature search in six electronic databases [Web of Science, PubMed, Embase, Cochrane Library, Sinomed, China National Knowledge Infrastructure (CNKI)] until October 2022.ResultsSeventeen eligible studies included 386 animals (254 received saponins and 132 received vehicles). The random effect model is used to calculate the combined effect. The effect size is expressed as the weighted average difference (WMD) and 95% confidence interval (CI). Compared with placebo, saponins preconditioning reduced infarct size after MIRI significantly (WMD: −3.60,95% CI: −4.45 to −2.74, P < 0.01, I2: 84.7%, P < 0.001), and significantly increased EF (WMD: 3.119, 95% CI: 2.165 to 4.082, P < 0.01, I2: 82.9%, P < 0.0 L) and FS (WMD: 3.157, 95% CI: 2.218 to 4.097, P < 0.001, I2: 81.3%, P < 0.001).DiscussionThe results show that the pre-administration of saponins from TCM has a significant protective effect on MIRI in preclinical studies, which provides an application prospect for developing anti-MIRI drugs with high efficiency and low toxicity.

【 授权许可】

Unknown   
© 2023 Sun, Fan, Yang, Su, Li, Tian, Liu and Xing.