Effects of different psychological interventions on quality of life and remission rate in patients with acute leukemia receiving chemotherapy: A randomized controlled trial

Frontiers in Psychology

Psychology

Fang Peng¹  Xiaoyun Li²  Huiyuan Li³  Haimiao Zhang⁴  Jingping Zhang⁵  Yifei Li⁵ 

[1] Changsha Social Work College, Changsha, China;Second Xiangya Hospital of Central South University, Changsha, China;The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China;The School of Nursing and Rehabilitation, Xi’an Medical University, Xi’an, China;Xiangya School of Nursing, Central South University, Changsha, China;

关键词: acute leukemia;    cognitive intervention;    progressive muscle relaxation;    quality of life;    remission;   

DOI  :  10.3389/fpsyg.2023.1045031

 received in 2022-09-15, accepted in 2023-01-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

AimsThis study aimed to examine and compare different psychological intervention effects on the quality of life (QoL) and remission rates of patients with acute leukemia receiving chemotherapy.MethodsA total of 180 participants were randomly divided into a cognitive intervention group, a progressive muscle relaxation (PMR) group, a cognitive intervention plus PMR group, and a usual care control group. QoL via the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 and remission rate were assessed at baseline and immediate post-intervention. A Generalized Linear Mixed Model was used for statistical analysis. Cost-effectiveness analysis with the value of the Incremental Cost-effectiveness Ratio was conducted to realize the economic evaluation of psychological interventions.ResultsThe total score of QoL and its most dimensions were significantly improved for participants in the intervention groups compared with the control group. The cognitive intervention plus PMR intervention was the most effective concerning QoL with cost-effectiveness. No significant improvements were indicated in participants’ remission rates among the groups.ConclusionThe cognitive intervention plus PMR intervention is the most effective in improving QoL with cost-effectiveness among patients with acute leukemia receiving chemotherapy. More rigorous randomized controlled trials with multiple follow-up points are suggested to clarify the psychological interventions on remission rates in this population.

【 授权许可】

Unknown   
Copyright © 2023 Peng, Li, Zhang, Li, Zhang and Li.