Analysis of the correlation between biomechanical properties and corneal densitometry in myopic eyes

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Xuan Chen¹  Yan Wang¹  Chao Xue¹  Yuwei Zheng²  Xiaohui Wang³  Jing Wang³ 

[1] Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China;Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, China;Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China;Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, China;The Second Affiliated Hospital of Anhui Medical University, Hefei, China;The Second Affiliated Hospital of Anhui Medical University, Hefei, China;

关键词: corneal densitometry;    Corvis ST;    small incision lenticule extraction (SMILE);    uniaxial tensile test;    biomechanic;   

DOI  :  10.3389/fbioe.2023.1182372

 received in 2023-03-08, accepted in 2023-04-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background: To investigate the correlation between corneal biomechanical characteristics (in vitro and in vivo) and corneal densitometry in myopia.Methods: The Pentacam (Oculus, Wetzlar, Germany) corneal densitometry (CD) and Corvis ST (Oculus, Wetzlar, Germany) exams were conducted prior to surgery for myopic patients who were intended to undergo small-incision lenticule extraction (SMILE). CD values (grayscale units, GSUs), and in vivo biomechanical parameters were obtained. The stromal lenticule was subjected to a uniaxial tensile test to obtain the elastic modulus E in vitro. We exam the correlations among in vivo, in vitro biomechanical characteristics and CD values.Results: In this study, 37 myopic patients (63 eyes) were included. The mean age of participants was 25.14 ± 6.74 years (range:16–39 years). The mean CD values of the total cornea, anterior layer, intermediate layer, posterior layer, 0–2 mm region and 2–6 mm region were 15.03 ± 1.23 GSU, 20.35 ± 1.98 GSU, 11.76 ± 1.01 GSU, 10.95 ± 0.83 GSU, 15.57 ± 1.12 GSU and 11.94 ± 1.77 GSU, respectively. Elastic modulus E (in vitro biomechanical indicator) was negatively correlated with intermediate layer CD (r = −0.35, p = 0.01) and 2–6 mm region CD (r = −0.39, p = 0.00). A negative correlation was also found between 0-2 mm central region CD and in vivo biomechanical indicator SP-HC (r = −0.29, p = 0.02).Conclusion: In myopic patients, densitometry is negatively correlated with biomechanical properties both in vivo and in vitro. With an increase in CD, the cornea deformed more easily.

【 授权许可】

Unknown   
Copyright © 2023 Zheng, Xue, Wang, Chen, Wang and Wang.