Health-related quality of life and functionality in primary caregiver of surviving pediatric COVID-19

Frontiers in Public Health

Public Health

Bruno Gualano¹  Camilla Astley¹  Priscila Suguita²  Vicente Odone-Filho²  Juliana C. O. A. Ferreira²  Artur F. Delgado²  Vera Bain²  Camila S. Y. Paula²  Nadia Litvinov²  Maria Fernanda B. Pereira²  Vitor Trindade²  Silvana Forsait²  Leila Antonangelo²  Livia Lindoso²  Clovis A. Silva²  Heloisa H. S. Marques²  Magda Carneiro-Sampaio²  Olivia M. Matsuo²  Thais T. Fink²  Fernanda Martins³  Denise Matheus⁴  Daniela S. Barboza⁴  Linamara R. Battistella⁵  Marta Imamura⁵  Fernanda T. Gonçalves⁶  Marilia M. Montenegro⁷  Simone Correa-Silva⁷  Patricia Palmeira⁷ 

[1] Faculdade de Medicina, Divisão de Reumatologia, Hospital das Clínicas, Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil;Faculdade de Medicina, Instituto da Criança e do Adolescente, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, SP, Brazil;Faculdade de Medicina, Instituto da Criança e do Adolescente, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, SP, Brazil;Instituto de Medicina Física e Reabilitação, Hospital das Clínicas HCFMUSP, São Paulo, SP, Brazil;Instituto de Medicina Física e Reabilitação, Hospital das Clínicas HCFMUSP, São Paulo, SP, Brazil;Instituto de Medicina Física e Reabilitação, Hospital das Clínicas HCFMUSP, São Paulo, SP, Brazil;Departamento de Medicina Legal, Bioética, Medicina do Trabalho e Medicina Física e Reabilitação, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil;Laboratorio de Imunohematologia e Hematologia Forense (LIM-40), Departamento de Medicina Legal, Bioética, Medicina do Trabalho e Medicina Física e Reabilitação, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, SP, Brazil;Laboratório de Pediatria Clínica (LIM-36), Departamento de Pediatria, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, SP, Brazil;

关键词: pediatric;    children;    adolescent;    COVID-19;    caregiver burden;    quality of life;    chronic disease;    public health;   

DOI  :  10.3389/fpubh.2023.1117854

 received in 2023-02-14, accepted in 2023-05-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesTo prospectively assess health-related quality of life (HRQoL), global functionality, and disability in primary caregivers of surviving children and adolescents after COVID-19.MethodsA longitudinal observational study was carried out on primary caregivers of surviving pediatric post-COVID-19 patients (n = 51) and subjects without COVID-19 (n = 60). EuroQol five-dimension five-level questionnaire (EQ-5D-5L) and 12-question WHO Disability Assessment Schedule 2.0 (WHODAS 2.0) were answered for both groups. The univariate regression analysis was carried out using SPSS (v 20) and significance was established at 5%.ResultsThe median duration between COVID-19 diagnosis in children and adolescents and longitudinal follow-up visits was 4.4 months (0.8–10.7). The median age of children and adolescents caregivers with laboratory-confirmed COVID-19 was similar to primary caregivers of subjects without laboratory-confirmed COVID-19 [43.2 (31.6–60.9) vs. 41.5 (21.6–54.8) years, p = 0.08], as well as similar female sex (p = 1.00), level of schooling (p = 0.11), social assistance program (p = 0.28), family income/month U$ (p = 0.25) and the number of household’s members in the residence (p = 0.68). The frequency of slight to extreme problems (level ≥ 2) of the pain/discomfort domain according to EQ-5D-5L score was significantly higher in the former group [74% vs. 52.5%, p = 0.03, OR = 2.57 (1.14–5.96)]. The frequency of disability according to WHODAS 2.0 total score was similar to those without disability and unknown (p = 0.79); however, with a very high disability in both groups (72.5% and 78.3%). Further analysis of primary caregivers of children and adolescents with post-COVID-19 condition (PCC) [n = 12/51 (23%)] compared to those without PCC [n = 39/51(77%)] revealed no differences between demographic data, EQ-5D-5L and WHODAS 2.0 scores in both groups (p > 0.05).ConclusionWe longitudinally demonstrated that pain/discomfort were predominantly reported in approximately 75% of primary caregiver of COVID-19 patients, with high disability in approximately three-quarters of both caregiver groups. These data emphasized the prospective and systematic caregiver burden evaluation relevance of pediatric COVID-19.

【 授权许可】

Unknown   
Copyright © 2023 Martins, Gonçalves, Imamura, Barboza, Matheus, Pereira, Marques, Correa-Silva, Montenegro, Fink, Lindoso, Bain, Ferreira, Astley, Matsuo, Suguita, Trindade, Paula, Litvinov, Palmeira, Gualano, Delgado, Carneiro-Sampaio, Forsait, Odone-Filho, Antonangelo, Battistella and Silva.