The causal relationship between genetically determined telomere length and meningiomas risk

Frontiers in Neurology

Neurology

Yunyun Mei¹  Liwei Zhou²  Fang Jia³  Sifang Chen⁴  Zhanxiang Wang⁴  Zhenwei Lu⁴  Weijie Yu⁴ 

[1] Department of Neurosurgery, Fudan University Shanghai Cancer Center (Xiamen Hospital), Xiamen, China;Department of Neurosurgery, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Brain Center, Xiamen, China;Department of Neurosurgery, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Brain Center, Xiamen, China;School of Medicine, Xiamen University, Xiamen, China;The School of Clinical Medicine, Fujian Medical University, Fuzhou, China;Department of Neurosurgery, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Brain Center, Xiamen, China;

关键词: Mendelian randomization;    meningiomas;    telomere length;    causality;    risk;   

DOI  :  10.3389/fneur.2023.1178404

 received in 2023-03-04, accepted in 2023-08-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundStudies have shown that longer leukocyte telomere length (LTL) is significantly associated with increased risk of meningioma. However, there is limited evidence concerning the causal association of LTL with benign and malignant meningiomas or with the location of benign tumors.MethodsWe used three LTL datasets from different sources, designated by name and sample size as LTL-78592, LTL-9190, and LTL-472174. The linkage disequilibrium score (LDSC) was used to explore the association between LTL and meningioma. We utilized two-sample bidirectional Mendelian randomization (TSMR) to evaluate whether LTL is causally related to meningioma risk. We adjusted for confounders by conducting multivariable Mendelian randomization (MVMR).ResultsIn the LTL-78592, longer LTL was significantly associated with increased risk of malignant [odds ratio (OR) = 5.14, p = 1.04 × 10−5], benign (OR = 4.81, p < 0.05), benign cerebral (OR = 5.36, p < 0.05), and benign unspecified meningioma (OR = 8.26, p < 0.05). The same results were obtained for the LTL-9190. In the LTL-472174, longer LTL was significantly associated with increased risk of malignant (OR = 4.94, p < 0.05), benign (OR = 3.14, p < 0.05), and benign cerebral meningioma (OR = 3.59, p < 0.05). Similar results were obtained in the MVMR. In contrast, only benign cerebral meningioma displayed a possible association with longer LTL (OR = 1.01, p < 0.05). No heterogeneity or horizontal pleiotropy was detected.ConclusionIn brief, genetically predicted longer LTL may increase the risk of benign, malignant, and benign cerebral meningiomas, regardless of the LTL measure, in European populations.

【 授权许可】

Unknown   
Copyright © 2023 Yu, Mei, Lu, Zhou, Jia, Chen and Wang.